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Topical and absorbable biomaterials for the local nitric oxide release

Grant number: 16/02414-5
Support type:Research Projects - Thematic Grants
Duration: February 01, 2017 - January 31, 2022
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Physical-Chemistry
Principal Investigator:Marcelo Ganzarolli de Oliveira
Grantee:Marcelo Ganzarolli de Oliveira
Home Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Co-Principal Investigators:Maria do Carmo Gonçalves
Assoc. researchers:Airton Goncalves Salles Junior ; Andréa Monte Alto Costa ; Celso Aparecido Bertran ; Eliana Aparecida de Rezende Duek ; Spero Penha Morato
Associated scholarship(s):19/07325-9 - Preparation of crosslinkable nitric oxide donor PAA/F127/PVA hybrid hydrogels for 3D printing, BP.IC
18/14142-5 - Hybrid hydrogels for local and prolonged nitric oxide release, BP.PD
18/12552-1 - Spin coating technique applied to the coating of ventricular assist device with nitric oxide releasing polyester films, BP.IC
+ associated scholarships 18/02520-5 - Nitric oxide-releasing stents comprised of bioabsorbable polinitrosated polyesters, BP.DD
17/12932-6 - 45S5 Bioglass Scaffolds to repare damages in bone tissue, BP.MS
17/19253-7 - Pluronic F127 thermosensitive hydrogels functionalized with terminal groups releasing nitric oxide, BP.PD
17/04615-0 - Nitric oxide releasing collagen membranes for bone regeneration, BP.IC - associated scholarships

Abstract

The development of novel biomedical technologies for tissue engineering and controlled drug delivery has demanded new platforms of degradable biomaterials capable of avoiding late complications in implantable devices. In turn, non-absorbable biomaterials for topical use have demanded new developments for improving their efficacies, especially for the topical treatment of chronic wounds. It is known that both tissue integration of implants and wound healing can benefit from the biological properties of locally released nitric oxide (NO). With this background, the objectives of this project are divided into two main categories of biomaterials: 1) NO-releasing implants and scaffolds and 2) topical NO-releasing hydrogels and include four main platforms: absorbable polyesters, bovine pericardium, bioglass and double network hydrogels. The polyesters will be used for the manufacturing of fully absorbable intracoronary stents and for the coating of ventricular assist device (VAD) and the bovine pericardium will be used for the manufacturing of the cardiac valves of the VAD. These platforms will be developed in collaboration with Dr. Ismar N. Cestari from the Tissue Engineering Laboratory of the Bioengineering Division of the Heart Institute, InCor-USP, and with Dr. Spero Penha Morato from Lasertools Technology. Nitrosated bioglasses and hybrid cellulose nanocrystals hydrogels will be developed in collaboration with Prof. Celso A. Bertran and Prof. Maria do Carmo Gonçalves, as main researchers of the Institute of Chemistry of Unicamp, respectively, in innovative approaches for bone tissue regeneration and for the topical treatment of wounds. (AU)

Scientific publications (18)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
PICHETH, GUILHERME F.; DA SILVA, LAURA C. E.; GIGLIO, LEONARDO P.; PLIVELIC, TOMAS S.; DE OLIVEIRA, MARCELO G. S-nitrosothiol-terminated Pluronic F127: Influence of microstructure on nitric oxide release. Journal of Colloid and Interface Science, v. 576, p. 457-467, SEP 15 2020. Web of Science Citations: 0.
GIGLIO, LEONARDO P.; PICHETH, GUILHERME F.; LOVSCHALL, KAJA BORUP; ZELIKIN, ALEXANDER N.; DE OLIVEIRA, MARCELO G. S-nitrosothiol-terminated poly(vinyl alcohol): Nitric oxide release and skin blood flow response. NITRIC OXIDE-BIOLOGY AND CHEMISTRY, v. 98, p. 41-49, MAY 1 2020. Web of Science Citations: 0.
GARZON-PORRAS, ANA M.; BERTUZZI, DIEGO L.; LUCAS, KURT; DA SILVA, LAURA C. E.; DE OLIVEIRA, MARCELO G.; ORNELAS, CATIA. Nitric Oxide Releasing Polyamide Dendrimer with Anti-inflammatory Activity. ACS APPLIED POLYMER MATERIALS, v. 2, n. 5, p. 2027-2034, MAY 2020. Web of Science Citations: 0.
POVOA, VALERIA C. O.; DOS SANTOS, GIOVANNA J. V. P.; PICHETH, GUILHERME F.; JARA, CARLOS P.; DA SILVA, LAURA C. E.; DE ARAUJO, ELIANA P.; DE OLIVEIRA, MARCELO G. Wound healing action of nitric oxide-releasing self-expandable collagen sponge. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, v. 14, n. 6 MAY 2020. Web of Science Citations: 0.
DA SILVA, LAURA C. E.; CASSAGO, ALEXANDRE; BATTIROLA, LILIANE C.; GONCALVES, MARIA CARMO; PORTUGAL, V, RODRIGO. Specimen preparation optimization for size and morphology characterization of nanocellulose by TEM. Cellulose, v. 27, n. 9 APR 2020. Web of Science Citations: 0.
CABRINI, FLAVIA MESQUITA; CHAMPEAU, MATHILDE; DE OLIVEIRA, MARCELO GANZAROLLI. Effect of Pluronic F127 on the 3D pore morphology of poly(N-isopropylacrylamide-co-acrylic acid) hydrogels and their nitric oxide release from S-nitrosoglutathione. Journal of Applied Polymer Science, v. 137, n. 36 FEB 2020. Web of Science Citations: 0.
DA SILVA, LAURA C. E.; BORGES, ANTONIO C.; DE OLIVEIRA, MARCELO G.; DE FARIAS, MARCELO A. Visualization of supramolecular structure of Pluronic F127 micellar hydrogels using cryo-TEM. METHODSX, v. 7, 2020. Web of Science Citations: 0.
THUROW, SAMUEL; FERNANDES, ALESSANDRA A. G.; QUEVEDO-ACOSTA, YOVANNY; DE OLIVEIRA, MATHEUS F.; DE OLIVEIRA, MARCELO G.; JURBERG, IGOR D. Preparation of Organic Nitrates from Aryldiazoacetates and Fe(NO3)(3)center dot 9H(2)O. ORGANIC LETTERS, v. 21, n. 17, p. 6909-6913, SEP 6 2019. Web of Science Citations: 1.
PICHETH, GUILHERME F.; MARINI, THATIANE C.; TALADRIZ-BLANCO, PATRICIA; SHIMAMOTO, GUSTAVO G.; DOS SANTOS, GIOVANNA J. V. P.; MENEAU, FLORIAN; DE OLIVEIRA, MARCELO G. Influence of Pluronic F127 microenvironments on the photochemical nitric oxide release from S-nitrosoglutathione. Journal of Colloid and Interface Science, v. 544, p. 217-229, MAY 15 2019. Web of Science Citations: 1.
DE SOUZA, GABRIELA FREITAS P.; DENADAI, JAQUELINE PRISCILLA; PICHETH, GUILHERME F.; DE OLIVEIRA, MARCELO GANZAROLLI. Long-term decomposition of aqueous S-nitrosoglutathione and S-nitroso-N-acetylcysteine: Influence of concentration, temperature, pH and light. NITRIC OXIDE-BIOLOGY AND CHEMISTRY, v. 84, p. 30-37, MAR 1 2019. Web of Science Citations: 2.
GERMINIANI, LUIZ G. L.; DA SILVA, LAURA C. E.; PLIVELIC, TOMAS S.; GONCALVES, MARIA C. Poly(epsilon-caprolactone)/cellulose nanocrystal nanocomposite mechanical reinforcement and morphology: the role of nanocrystal pre-dispersion. Journal of Materials Science, v. 54, n. 1, p. 414-426, JAN 2019. Web of Science Citations: 2.
BALDIM, VICTOR; DE OLIVEIRA, MARCELO G. Poly-epsilon-caprolactone/polysulfhydrylated polyester blend: A platform for topical and degradable nitric oxide-releasing materials. EUROPEAN POLYMER JOURNAL, v. 109, p. 143-152, DEC 2018. Web of Science Citations: 0.
ZANATA, DANIELA DE MORAIS; BATTIROLA, LILIANE CRISTINA; GONCALVES, MARIA DO CARMO. Chemically cross-linked aerogels based on cellulose nanocrystals and polysilsesquioxane. Cellulose, v. 25, n. 12, p. 7225-7238, DEC 2018. Web of Science Citations: 2.
BATTIROLA, LILIANE C.; ZANATA, DANIELA M.; GONCALVES, MARIA C. Improvement of cellulose acetate dimensional stability by chemical crosslinking with cellulose nanocrystals. COMPOSITES PART A-APPLIED SCIENCE AND MANUFACTURING, v. 113, p. 105-113, OCT 2018. Web of Science Citations: 2.
CHAMPEAU, MATHILDE; POVOA, VALERIA; MILITAO, LUCAS; CABRINI, FLAVIA M.; PICHETH, GUILHERME F.; MENEAU, FLORIAN; JARA, CARLOS P.; DE ARAUJO, ELIANA P.; DE OLIVEIRA, MARCELO G. Supramolecular poly(acrylic acid)/F127 hydrogel with hydration-controlled nitric oxide release for enhancing wound healing. Acta Biomaterialia, v. 74, p. 312-325, JUL 1 2018. Web of Science Citations: 12.
DA SILVA, LAURA C. E.; GERMINIANI, LUIZ G. L.; PLIVELIC, TOMAS S.; GONCALVES, MARIA C. Solvent-free and biocompatible multiphased organic-inorganic hybrid nanocomposites. SOFT MATTER, v. 14, n. 9, p. 1709-1718, MAR 7 2018. Web of Science Citations: 3.
ABALDE-CELA, SARA; TALADRIZ-BLANCO, PATRICIA; DE OLIVEIRA, MARCELO GANZAROLLI; ABELL, CHRIS. Droplet microfluidics for the highly controlled synthesis of branched gold nanoparticles. SCIENTIFIC REPORTS, v. 8, FEB 5 2018. Web of Science Citations: 18.
LOURENCO, SARAH DE M.; DE OLIVEIRA, MARCELO G. Topical photochemical nitric oxide release from porous poly(vinyl alcohol) membrane for visible light modulation of dermal vasodilation. JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY, v. 346, p. 548-558, SEP 1 2017. Web of Science Citations: 5.

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