Abstract
The development of novel biomedical technologies for tissue engineering and controlled drug delivery has demanded new platforms of degradable biomaterials capable of avoiding late complications in implantable devices. In turn, non-absorbable biomaterials for topical use have demanded new developments for improving their efficacies, especially for the topical treatment of chronic wounds. It is known that both tissue integration of implants and wound healing can benefit from the biological properties of locally released nitric oxide (NO). With this background, the objectives of this project are divided into two main categories of biomaterials: 1) NO-releasing implants and scaffolds and 2) topical NO-releasing hydrogels and include four main platforms: absorbable polyesters, bovine pericardium, bioglass and double network hydrogels. The polyesters will be used for the manufacturing of fully absorbable intracoronary stents and for the coating of ventricular assist device (VAD) and the bovine pericardium will be used for the manufacturing of the cardiac valves of the VAD. These platforms will be developed in collaboration with Dr. Ismar N. Cestari from the Tissue Engineering Laboratory of the Bioengineering Division of the Heart Institute, InCor-USP, and with Dr. Spero Penha Morato from Lasertools Technology. Nitrosated bioglasses and hybrid cellulose nanocrystals hydrogels will be developed in collaboration with Prof. Celso A. Bertran and Prof. Maria do Carmo Gonçalves, as main researchers of the Institute of Chemistry of Unicamp, respectively, in innovative approaches for bone tissue regeneration and for the topical treatment of wounds. (AU)
Scientific publications
(18)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
GARZON-PORRAS, ANA M.;
BERTUZZI, DIEGO L.;
LUCAS, KURT;
DA SILVA, LAURA C. E.;
DE OLIVEIRA, MARCELO G.;
ORNELAS, CATIA.
Nitric Oxide Releasing Polyamide Dendrimer with Anti-inflammatory Activity.
ACS APPLIED POLYMER MATERIALS,
v. 2,
n. 5,
p. 2027-2034,
MAY 2020.
Web of Science Citations: 0.
THUROW, SAMUEL;
FERNANDES, ALESSANDRA A. G.;
QUEVEDO-ACOSTA, YOVANNY;
DE OLIVEIRA, MATHEUS F.;
DE OLIVEIRA, MARCELO G.;
JURBERG, IGOR D.
Preparation of Organic Nitrates from Aryldiazoacetates and Fe(NO3)(3)center dot 9H(2)O.
ORGANIC LETTERS,
v. 21,
n. 17,
p. 6909-6913,
SEP 6 2019.
Web of Science Citations: 1.
PICHETH, GUILHERME F.;
MARINI, THATIANE C.;
TALADRIZ-BLANCO, PATRICIA;
SHIMAMOTO, GUSTAVO G.;
DOS SANTOS, GIOVANNA J. V. P.;
MENEAU, FLORIAN;
DE OLIVEIRA, MARCELO G.
Influence of Pluronic F127 microenvironments on the photochemical nitric oxide release from S-nitrosoglutathione.
Journal of Colloid and Interface Science,
v. 544,
p. 217-229,
MAY 15 2019.
Web of Science Citations: 1.
CHAMPEAU, MATHILDE;
POVOA, VALERIA;
MILITAO, LUCAS;
CABRINI, FLAVIA M.;
PICHETH, GUILHERME F.;
MENEAU, FLORIAN;
JARA, CARLOS P.;
DE ARAUJO, ELIANA P.;
DE OLIVEIRA, MARCELO G.
Supramolecular poly(acrylic acid)/F127 hydrogel with hydration-controlled nitric oxide release for enhancing wound healing.
Acta Biomaterialia,
v. 74,
p. 312-325,
JUL 1 2018.
Web of Science Citations: 12.