Advanced search
Start date
Betweenand

3D printing of nitric oxide-releasing hybrid hydrogels based on poly(2-hydroxyethyl methacrylate) and polysilsescoyxane

Grant number: 20/16804-5
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): August 01, 2021
Effective date (End): July 31, 2022
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Physical-Chemistry
Principal researcher:Marcelo Ganzarolli de Oliveira
Grantee:Giovana Bosso Romano
Home Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Associated research grant:16/02414-5 - Topical and absorbable biomaterials for the local nitric oxide release, AP.TEM

Abstract

The multiple physiological actions of nitric oxide (NO), including the vasodilation and the acceleration of wound healing, have motivated the development of biomaterials for local NO re-lease. Poly(2-hydroxyethyl methacrylate) (PHEMA) hydrogels are widely used for the manufacturing of contact lenses. More recently the presence of vinyl groups in the monomer has allowed the 3D printing of constructs for specific applications. The main aim of the present project is the development of NO-releasing hybrid-organic-inorganic hydrogels based on PHEMA and polysilsesquioxane for light-assisted 3D printing. The hydrogels will be prepared from the hydrolysis and condensation of the triethoxysilyl groups chemically bound to the 2-hydroxyethyl methacrylate molecules, generating silsesquioxane nanostructures containing surface methacrylate groups and further charged with the NO donor S-nitrosoglutathione (GSNO). The hydrogels will be characterized regarding their compressibility, swelling capacity morphology, and NO release profiles. (AU)

News published in Agência FAPESP Newsletter about the scholarship:
Articles published in other media outlets (0 total):
More itemsLess items
VEICULO: TITULO (DATA)
VEICULO: TITULO (DATA)