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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Genome-wide association study for milk production traits in a Brazilian Holstein population

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Autor(es):
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Iung, L. H. S. [1] ; Petrini, J. [1] ; Ramirez-Diaz, J. [1] ; Salvian, M. [1] ; Rovadoscki, G. A. [1] ; Pilonetto, F. [1] ; Dauria, B. D. [1] ; Machado, P. F. [1] ; Coutinho, L. L. [1] ; Wiggans, G. R. [2] ; Mourao, G. B. [1]
Número total de Autores: 11
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Dept Anim Sci, Luiz Queiroz Coll Agr ESALQ, BR-13418900 Piracicaba, SP - Brazil
[2] USDA, Anim Genom & Improvement Lab, ARS, Beltsville, MD 20705 - USA
Número total de Afiliações: 2
Tipo de documento: Artigo Científico
Fonte: JOURNAL OF DAIRY SCIENCE; v. 102, n. 6, p. 5305-5314, JUN 2019.
Citações Web of Science: 1
Resumo

Advances in the molecular area of selection have expanded knowledge of the genetic architecture of complex traits through genome-wide association studies (GWAS). Several GWAS have been performed so far, but confirming these results is not always possible due to several factors, including environmental conditions. Thus, our objective was to identify genomic regions associated with traditional milk production traits, including milk yield, somatic cell score, fat, protein and lactose percentages, and fatty acid composition in a Holstein cattle population producing under tropical conditions. For this, 75,228 phenotypic records from 5,981 cows and genotypic data of 56,256 SNP from 1,067 cows were used in a weighted single-step GWAS. A total of 46 windows of 10 SNP explaining more than 1% of the genetic variance across 10 Bos taurus autosomes (BTA) harbored well-known and novel genes. The MGST1 (BTA5), ABCG2 (BTA6), DGAT1 (BTA14), and PAEP (BTA11) genes were confirmed within some of the regions identified in our study. Potential novel genes involved in tissue damage and repair of the mammary gland (COL18A1), immune response (LTTC19), glucose homeostasis (SLC37A1), synthesis of unsaturated fatty acids (LTBP1), and sugar transport (SLC37A1 and MFSD4A) were found for milk yield, somatic cell score, fat percentage, and fatty acid composition. Our findings may assist genomic selection by using these regions to design a customized SNP array to improve milk production traits on farms with similar environmental conditions. (AU)

Processo FAPESP: 12/15948-7 - Incorporação de informações genômicas no desenvolvimento de índices econômicos para a seleção de bovinos leiteiros
Beneficiário:Juliana Petrini
Linha de fomento: Bolsas no Brasil - Doutorado
Processo FAPESP: 12/24788-3 - Interações epistáticas entre SNPs associados à composição e perfil de ácidos graxos no leite bovino
Beneficiário:Laiza Helena de Souza Iung
Linha de fomento: Bolsas no Brasil - Mestrado
Processo FAPESP: 10/12929-6 - Análise genética quantitativo-molecular para características de produção, perfil de ácidos graxos e qualidade do leite
Beneficiário:Gerson Barreto Mourão
Linha de fomento: Auxílio à Pesquisa - Regular