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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Genome-wide association study for milk production traits in a Brazilian Holstein population

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Iung, L. H. S. [1] ; Petrini, J. [1] ; Ramirez-Diaz, J. [1] ; Salvian, M. [1] ; Rovadoscki, G. A. [1] ; Pilonetto, F. [1] ; Dauria, B. D. [1] ; Machado, P. F. [1] ; Coutinho, L. L. [1] ; Wiggans, G. R. [2] ; Mourao, G. B. [1]
Total Authors: 11
[1] Univ Sao Paulo, Dept Anim Sci, Luiz Queiroz Coll Agr ESALQ, BR-13418900 Piracicaba, SP - Brazil
[2] USDA, Anim Genom & Improvement Lab, ARS, Beltsville, MD 20705 - USA
Total Affiliations: 2
Document type: Journal article
Source: JOURNAL OF DAIRY SCIENCE; v. 102, n. 6, p. 5305-5314, JUN 2019.
Web of Science Citations: 1

Advances in the molecular area of selection have expanded knowledge of the genetic architecture of complex traits through genome-wide association studies (GWAS). Several GWAS have been performed so far, but confirming these results is not always possible due to several factors, including environmental conditions. Thus, our objective was to identify genomic regions associated with traditional milk production traits, including milk yield, somatic cell score, fat, protein and lactose percentages, and fatty acid composition in a Holstein cattle population producing under tropical conditions. For this, 75,228 phenotypic records from 5,981 cows and genotypic data of 56,256 SNP from 1,067 cows were used in a weighted single-step GWAS. A total of 46 windows of 10 SNP explaining more than 1% of the genetic variance across 10 Bos taurus autosomes (BTA) harbored well-known and novel genes. The MGST1 (BTA5), ABCG2 (BTA6), DGAT1 (BTA14), and PAEP (BTA11) genes were confirmed within some of the regions identified in our study. Potential novel genes involved in tissue damage and repair of the mammary gland (COL18A1), immune response (LTTC19), glucose homeostasis (SLC37A1), synthesis of unsaturated fatty acids (LTBP1), and sugar transport (SLC37A1 and MFSD4A) were found for milk yield, somatic cell score, fat percentage, and fatty acid composition. Our findings may assist genomic selection by using these regions to design a customized SNP array to improve milk production traits on farms with similar environmental conditions. (AU)

FAPESP's process: 12/15948-7 - Inclusion of genomic information in the development of economic index for dairy cattle selection
Grantee:Juliana Petrini
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 12/24788-3 - Epistatic interactions between SNPs associated with composition and fatty acid profile in bovine milk
Grantee:Laiza Helena de Souza Iung
Support type: Scholarships in Brazil - Master
FAPESP's process: 10/12929-6 - Quantitative-molecular genetic analysis for production traits, fatty acid profile and milk quality
Grantee:Gerson Barreto Mourão
Support type: Regular Research Grants