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Epistatic interactions between SNPs associated with composition and fatty acid profile in bovine milk

Grant number: 12/24788-3
Support type:Scholarships in Brazil - Master
Effective date (Start): January 01, 2014
Effective date (End): July 31, 2014
Field of knowledge:Agronomical Sciences - Animal Husbandry - Genetics and Improvement of Domestic Animals
Principal Investigator:Gerson Barreto Mourão
Grantee:Laiza Helena de Souza Iung
Home Institution: Escola Superior de Agricultura Luiz de Queiroz (ESALQ). Universidade de São Paulo (USP). Piracicaba , SP, Brazil

Abstract

The appeal of consumers for better quality nutritional food is propelling the industry and research to meet these demands. In dairy cattle, the composition and fatty acid profile in milk has been one of the targets, mainly due to the inconsistency between the relationship of these compounds in milk and human requirement. Several tools are available and are able to promote changes in milk composition, among them the recently combined traditional animal breeding with molecular genetics, providing a faster genetic progress in these traits. With the advent of discovery in large-scale of SNPs (Single Nucleotide Polymorphisms) markers made possible the development of a methodology that allows the association between phenotypic measures with specific genotypes. These advances in molecular area allow expanding the knowledge about the genetic architecture of traits, such as epistatic interactions between genes. Thus, the aim of this study is to identify epistatic interactions between SNPs markers associated with composition and fatty acid profile in bovine milk. For this, we will use genomic and phenotypic information (n = 800) of traits related to the composition and fatty acid profile in milk of Holstein cows which will be analyzed in an animal model.

Scientific publications (5)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CARRARA, EULA REGINA; GAYA, LEILA DE GENOVA; DE PAIVA, JOSE TEODORO; PETRINI, JULIANA; SALVIAN, MAYARA; ROVADOSCKI, GREGORI ALBERTO; REIS, ARICIA CHAVES ZANETTI; MACHADO, PAULO FERNANDO; MOURAO, GERSON BARRETO. Impact of inbreeding on milk fatty acids of a Brazilian Holstein cattle. ANIMAL PRODUCTION SCIENCE, v. 60, n. 12 APR 2020. Web of Science Citations: 0.
PETRINI, JULIANA; DE SOUZA IUNG, LAIZA HELENA; PETERSEN RODRIGUEZ, MARY ANA; SALVIAN, MAYARA; ROVADOSCKI, GREGORI ALBERTO; ROBLES COLONIA, SADITT ROCIO; CASSOLI, LAERTE DAGHER; COUTINHO, LUIZ LEHMANN; MACHADO, PAULO FERNANDO; WIGGANS, GEORGE; MOURAO, GERSON BARRETO. Assessing the accuracy of prediction for milk fatty acids by using a small reference population of tropical Holstein cows. JOURNAL OF ANIMAL BREEDING AND GENETICS, v. 136, n. 6, p. 453-463, NOV 2019. Web of Science Citations: 0.
CARRARA, EULA REGINA; GAYA, LEILA DE GENOVA; PETRINI, JULIANA; DE PAIVA, JOSE TEODORO; SALVIAN, MAYARA; ROVADOSCKI, GREGORI ALBERTO; MACHADO, PAULO FERNANDO; MOURAO, GERSON BARRETO. Genetic and phenotypic trends for milk fatty acids in a Holstein cattle population reared under tropical conditions. LIVESTOCK SCIENCE, v. 228, p. 84-92, OCT 2019. Web of Science Citations: 0.
PETRINI, JULIANA; DE SOUZA IUNG, LAIZA HELENA; PETERSEN RODRIGUEZ, MARY ANA; SALVIAN, MAYARA; ROVADOSCKI, GREGORI ALBERTO; ROBLES COLONIA, SADITT ROCIO; CASSOLI, LAERTE DAGHER; COUTINHO, LUIZ LEHMANN; MACHADO, PAULO FERNANDO; WIGGANS, GEORGE; MOURAO, GERSON BARRETO. Assessing the accuracy of prediction for milk fatty acids by using a small reference population of tropical Holstein cows. JOURNAL OF ANIMAL BREEDING AND GENETICS, AUG 2019. Web of Science Citations: 0.
IUNG, L. H. S.; PETRINI, J.; RAMIREZ-DIAZ, J.; SALVIAN, M.; ROVADOSCKI, G. A.; PILONETTO, F.; DAURIA, B. D.; MACHADO, P. F.; COUTINHO, L. L.; WIGGANS, G. R.; MOURAO, G. B. Genome-wide association study for milk production traits in a Brazilian Holstein population. JOURNAL OF DAIRY SCIENCE, v. 102, n. 6, p. 5305-5314, JUN 2019. Web of Science Citations: 1.
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
IUNG, Laiza Helena de Souza. Additive, dominance and epistatic association with milk yield and composition in Holstein cattle. 2014. Master's Dissertation - Universidade de São Paulo (USP). Escola Superior de Agricultura Luiz de Queiroz Piracicaba.

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