The postprandial inflammatory response is attenuated by a dietary structured lipid containing behenic acid

Autor(es)

da Silva, Reginaldo Marques ^[1] ; Taketa Moreira, Debora Kono ^[2] ; Zarricueta, Melina Luzzi ^[1] ; Rabelo e Paiva Caria, Antia ^[1] ; Macedo, Juliana Alves ^[2] ; Macedo, Gabriela Alves ^[2] ; Gambero, Alessandra ^[3]

Afiliação do(s) autor(es)

^[1] Sao Francisco Univ, Hlth Sci Postgrad Program, Braganca Paulista, SP - Brazil

^[2] Univ Estadual Campinas, Dept Food & Nutr, Sch Food Engn, Campinas, SP - Brazil

^[3] Univ Estadual Campinas, Chem Biol & Agr Pluridisciplinary Res Ctr CPQBA, Campinas, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Journal of Functional Foods; v. 58, p. 350-354, JUL 2019.
• Citações Web of Science: 0

Resumo

A high-fat meal can induce a postprandial inflammatory response, characterized mainly by increased serum levels of interleukin (IL)-6 and endotoxemia. We developed a structured lipid rich in behenic acid via enzymatic interesterification of a blend of soy, olive, and fully hydrogenated crambe oil, and evaluated its ability to induce postprandial inflammation in mice. Triglyceride absorption was reduced after consumption of a meal containing 15% of this structured lipid. The postprandial IL-6, lipopolysaccharide (LPS), C-reactive protein, and insulin levels were similar to those in mice that received a low-fat diet. Gastric emptying and satiety hormone serum levels did not differ between the experimental groups. Our data showed that a structured lipid containing behenic acid has a reduced ability to induce postprandial inflammation, suggesting that the introduction of modified dietary fat into a diet could be beneficial for health. (AU)

• Processo FAPESP: 17/00457-1 - "Lipídeo estruturado contendo ácido behênico na obesidade e inflamação".
• Beneficiário: Alessandra Gambero
• Modalidade de apoio: Auxílio à Pesquisa - Regular