Comparative physiology investigations support a role for histidine-containing dipeptides in intracellular acid base regulation of skeletal muscle

Autor(es)

Dolan, Eimear ^[1] ; Saunders, Bryan ^{[1, 2]} ; Harris, Roger Charles ^[3] ; Bicudo, Jose Eduardo Pereira Wilken ^[4] ; Bishop, David John ^{[5, 6]} ; Sale, Craig ^[7] ; Gualano, Bruno ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Rheumatol Div, Appl Physiol & Nutr Res Grp, Fac Med FMUSP, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Inst Orthopaed & Traumatol, Fac Med FMUSP, Sao Paulo - Brazil

^[3] Junipa Ltd, Newmarket, Suffolk - England

^[4] Univ Wollongong, Sch Biol Sci, Wollongong, NSW - Australia

^[5] Victoria Univ, Inst Hlth & Sport IHes, Coll Sport & Exercise Sci, Melbourne, Vic - Australia

^[6] Edith Cowan Univ, Sch Med & Hlth Sci, Churchlands, WA - Australia

^[7] Nottingham Trent Univ, Sch Sci & Technol, Musculoskeletal Physiol Res Grp, Sport Hlth & Performance Enhancement Res Ctr, Nottingham - England

• Tipo de documento: Artigo de Revisão
• Fonte: COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY; v. 234, p. 77-86, AUG 2019.
• Citações Web of Science: 2

Resumo

Histidine containing dipeptides (HCDs: carnosine, anserine and balenine) have numerous therapeutic and ergogenic properties, but there is a lack of consensus on the mechanistic pathways through which they function. Potential roles include intracellular buffering, neutralisation of reactive species, and calcium regulation. Comparative investigations of the HCD content of various species provide unique insight into their most likely mechanisms of action. This review chronologically describes how the comparative physiology studies, conducted since the beginning of the 20th century, have shaped our understanding of the physiological roles of HCDs. The investigation of a wide range of physiologically distinct species indicates that those species with a strong reliance on non-oxidative forms of energy production are abundant in HCDs. These include: whales who experience long periods of hypoxia while diving; racehorses and greyhound dogs who have highly developed sprint abilities, and chickens and turkeys whose limited capacity for flight is largely fuelled by their white, glycolytic, muscle. Additionally, a higher HCD content in the Type 2 muscle fibres of various species (which have greater capacity for non-oxidative metabolism) was consistently observed. The pKa of the HCDs render them ideally suited to act as intracellular physicochemical buffers within the pH transit range of the skeletal muscle. As such, their abundance in species which show a greater reliance on non-oxidative forms of energy metabolism, and which experience regular challenges to acid-base homeostasis, provides strong evidence that intracellular proton buffering is an important function of the HCDs in skeletal muscle. (AU)

• Processo FAPESP: 13/14746-4 - Metabolismo da carnosina no músculo esquelético: um estudo de múltiplas abordagens
• Beneficiário: Bruno Gualano
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 17/04973-4 - Suplementação nutricional e exercício para otimizar o desempenho: foco nas respostas individuais e um passo para a nutrição esportiva personalizada
• Beneficiário: Bryan Saunders
• Modalidade de apoio: Bolsas no Brasil - Jovens Pesquisadores
• Processo FAPESP: 16/50438-0 - Suplementação nutricional e exercício para otimizar o desempenho: foco nas respostas individuais e um passo para a nutrição esportiva personalizada
• Beneficiário: Bryan Saunders
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores
• Processo FAPESP: 17/09635-0 - Fatores que determinam o conteúdo de carnosina no músculo esquelético humano: Influência da idade e do sexo
• Beneficiário: Eimear Bernadette Dolan
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 15/11328-2 - Metabolismo da carnosina no músculo esquelético: um estudo de múltiplas abordagens. Sub-estudo 3: explorando o papel da carnosina no músculo esquelético
• Beneficiário: Eimear Bernadette Dolan
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado