Fluoroquinolones in Hospital Wastewater: Analytical Method, Occurrence, Treatment with Ozone and Residual Antimicrobial Activity Evaluation

Autor(es)

Rodrigues-Silva, Caio ^[1] ; Porto, Rafael S. ^[1] ; dos Santos, Sabrina G. ^[1] ; Schneider, Jerusa ^[2] ; Rath, Susanne ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, Inst Quim, Dept Quim Analit, CP 6154, BR-13083970 Campinas, SP - Brazil

^[2] Univ Estadual Campinas, Fac Engn Civil Arquitetura & Urbanismo, CP 6143, BR-13083889 Campinas, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Journal of the Brazilian Chemical Society; v. 30, n. 7, p. 1447-1457, JUL 2019.
• Citações Web of Science: 0

Resumo

Fluoroquinolones antimicrobials are partially excreted in natura after administration. Their occurrence was investigated in hospital raw sewage (HRS) and treated wastewater (TW) using an online solid phase extraction-ultra high-performance liquid chromatography-tandem mass spectrometry method (SPE-UHPLC-MS/MS). The analytical curves ranged from 0.25 to 46 ng mL-1 and the matrix effect, assessed for marbofloxacin and lomefloxacin, ranged from –63 to +1%. All HRS samples contained ciprofloxacin (1-34 ng mL-1) and ofloxacin (0.9-27 ng mL-1), while norfloxacin was detected in 17% of the samples (0.8-4.4 ng mL-1). Only ciprofloxacin (0.5-5.6 ng mL-1) was detected in TW samples. The antimicrobial activity of the HRS samples for E. coli was higher than a ciprofloxacin solution of 1 mg L-1, due to the presence of other antimicrobial agents. Ozonation (10 mg O3 L-1 min-1 ; 10 min) degraded up to 84% of the fluoroquinolones and removed the antimicrobial activity of HRS samples. (AU)

• Processo FAPESP: 13/09543-7 - Resíduos de medicamentos veterinários no ambiente
• Beneficiário: Susanne Rath
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 18/03571-2 - Fármacos no Ecossistema Aquático
• Beneficiário: Susanne Rath
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 14/50951-4 - INCT 2014: Tecnologias Analíticas Avançadas
• Beneficiário: Celio Pasquini
• Modalidade de apoio: Auxílio à Pesquisa - Temático