HIV-1 reverse transcriptase inhibitory activity of flavones and chlorogenic acid derivatives from Moquiniastrum floribundum (Asteraceae)

Autor(es)

Tamayose, C. I. ^[1] ; Torres, P. B. ^[2] ; Roque, N. ^[3] ; Ferreira, M. J. P. ^[2]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Inst Quim, BR-05508000 Sao Paulo - Brazil

^[2] Univ Sao Paulo, Dept Bota, Inst Biociencias, BR-05508090 Sao Paulo - Brazil

^[3] Univ Fed Bahia, Inst Biol, BR-40170290 Salvador, BA - Brazil

• Tipo de documento: Artigo Científico
• Fonte: SOUTH AFRICAN JOURNAL OF BOTANY; v. 123, p. 142-146, JUL 2019.
• Citações Web of Science: 2

Resumo

In the search for new bioactive natural products, plant sources represent a particularly suitable starting point in drug discovery. Among natural products, phenolic derivatives have a prominent place with several compounds exhibiting remarkable activities. This paper described the phenolic composition of Moquiniastrum floribundum (Asteraceae) and evaluated the inhibitory effect of isolated compounds on HIV-1 reverse transcriptase. From M. floribundum was isolated three flavones, genkwanin (1), hispidulin (2), and cirsimaritin (3), and eight chlorogenic acid derivatives, 4,5-di-O-caffeoylquinic acid (4), 3,5-di-O-caffeoylquinic acid (5), 3,4-di-O-caffeoylquinic acid (6), 3,5-di-O-caffeoylquinic acid methyl ester (7), 3,4,5-tri-O-caffeoylquinic acid methyl ester (8), 3-O-caffeoylquinic acid (9), 4-O-caffeoylquinic acid (10) and 5-O-caffeoylquinic acid (11). The most active compound was 4,5-di-O-caffeoylquinic acid (4), with 65.0 +/- 7.9% of inhibitory activity on HIV-1 reverse transcriptase and IC50 0.240 mmol L-1. (C) 2019 SAAB. Published by Elsevier B.V. All rights reserved. (AU)

• Processo FAPESP: 14/20932-8 - ESTUDO FITOQUÍMICO, QUIMIOSSISTEMÁTICO E ATIVIDADES BIOLÓGICAS DE ESPÉCIES DE Moquiniastrum E Richterago
• Beneficiário: Cinthia Indy Tamayose
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 14/21593-2 - Baccharis L. (Asteraceae) e fungos endofíticos associados: metabólitos secundários e atividades biológicas
• Beneficiário: Marcelo José Pena Ferreira
• Modalidade de apoio: Auxílio à Pesquisa - Regular