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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

The association between genetic risk score and blood pressure is modified by coffee consumption: Gene-diet interaction analysis in a population-based study

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Autor(es):
Miranda, Andreia Machado [1] ; Steluti, Josiane [1] ; Norde, Marina Maintinguer [1] ; Fisberg, Regina Mara [1] ; Marchioni, Dirce Maria [1]
Número total de Autores: 5
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Sch Publ Hlth, Dept Nutr, Av Dr Arnaldo 715, BR-01246904 Sao Paulo, SP - Brazil
Número total de Afiliações: 1
Tipo de documento: Artigo Científico
Fonte: Clinical Nutrition; v. 38, n. 4, p. 1721-1728, AUG 2019.
Citações Web of Science: 0
Resumo

Background \& aim: Recent genome-wide association studies (GWAS) have identified single nucleotide polymorphisms (SNPs) that are associated with high blood pressure (BP). However, whether coffee consumption interacts with the genetic variants related to BP is yet unclear. Thus, this study aimed to investigate whether the association between genetic risk core (GRS) and blood pressure was modified by usual coffee consumption. Methods: Data were from the `Health Survey of Sao Paulo' a cross-sectional population-based survey, among 533 participants aged 20 years or older. Coffee consumption was estimated by two 24-h dietary recalls and categorized into <1,1-3, and >3 cups/day. The GRS was calculated based on SNPs in previous GWAS {[}CYP1A1/CYP1A2 (rs2470893, rs2472297); CPLX3/ULK3 (rs6495122); MTHFR (rs17367504)]. Multiple logistic regression analysis were performed to estimate the associations between GRS with high BP, and both, high systolic BP (SBP) and diastolic BP (DBP); and the multiplicative interaction term between the GRS and coffee consumption were tested by including in the models. Results: Higher GRS independently contributed to higher probability of elevated BP, SBP and DBP in this population (OR = 1.85, 95%CI = 1.19-2.87; OR = 2.30, 95%CI = 1.32-4.01 and OR = 1.66, 95%CI = 1.10 2.51; respectively). Moreover, there were a significant interaction effects for coffee consumption and GRS on the high BP, SBP and DBP. Individuals with higher BP increasing alleles in the GRS had a significantly high BP (OR = 5.09, 95%CI = 1.32-19.7), and both elevated SBP and DBP (OR = 2.14, 95% CI = 1.12-4.11; OR = 3.54, 95%CI = 1.17-10.75), among those with high coffee consumption (>3 cups coffee/day). Conclusions: Consumption of coffee could interact with genetic predisposition in relation to BR Thus, the GRS for high BP is modified by coffee consumption. Individuals with greater GRS appeared to have high BP associated with higher coffee consumption, highlighting the particular importance to reduce coffee intake in individuals genetically predisposed to this cardiovascular disease risk factor. (C) 2018 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved. (AU)

Processo FAPESP: 14/04540-2 - Estudo epidemiológico do consumo do café, sua contribuição na ingestão de polifenóis e seus potenciais efeitos nos fatores de risco cardiovascular, considerando variações genéticas individuais
Beneficiário:Andreia Alexandra Machado Miranda
Linha de fomento: Bolsas no Brasil - Doutorado