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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Electrodiagnosis of dichromacy

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Autor(es):
Salgueiro Barboni, Mirella Telles [1, 2] ; Hauzman, Einat [3, 2] ; Nagy, Balazs Vince [4, 2] ; Gomes Martins, Cristiane Maria [2] ; Aher, Avinash J. [5] ; Tsai, I, Tina ; Oliveria Bonci, Daniela Maria [3, 2] ; Ventura, Dora Fix [3, 2] ; Kremers, Jan [6, 7]
Número total de Autores: 9
Afiliação do(s) autor(es):
[1] Semmelweis Univ, Dept Ophthalmol, Budapest - Hungary
[2] Univ Sao Paulo, Dept Expt Psychol, Av Prof Mello Moraes 1721, BR-05508030 Sao Paulo - Brazil
[3] Inst Israelita Ensino & Pesquisa Albert Einstein, Sao Paulo - Brazil
[4] Budapest Univ Technol & Econ, Dept Mechatron Opt & Engn Informat, Budapest - Hungary
[5] Univ Hosp, Dept Ophthalmol, Erlangen - Germany
[6] Tsai, Tina, I, Univ Hosp, Dept Ophthalmol, Erlangen - Germany
[7] FAU Erlangen Nurnberg, Dept Biol Anim Physiol, Erlangen - Germany
Número total de Afiliações: 7
Tipo de documento: Artigo Científico
Fonte: VISION RESEARCH; v. 158, p. 135-145, MAY 2019.
Citações Web of Science: 0
Resumo

Retinal and cortical signals initiated by a single cone type can be recorded using the spectral compensation (or silent substitution) paradigm. Moreover, responses to instantaneous excitation increments combined with gradual excitation decreases are dominated by the response to the excitation increment. Similarly, the response to a sudden excitation decrement dominates the overall response when combined with a gradual excitation increase. Here ERGS and VEPs were recorded from 34 volunteers {[}25.9 +/- 10.4 years old (mean +/- SD); 25 males, 9 females] to sawtooth flicker (4 Hz) stimuli that elicited L- or M-cone responses using triple silent substitution. The mean luminance (284 cd/m(2)) and the mean chromaticity (x = 0.5686, y = 0.3716; CIE 1931 color space) remained constant and thus the state of adaptation was the same in all conditions. Color discrimination thresholds along protan, deutan, and tritan axes were obtained from all participants. Dichromatic subjects were genetically characterized by molecular analysis of their opsin genes. ERG responses to L-cone stimuli were absent in protanopes whereas ERG responses to M-cone stimuli were strongly reduced in deuteranopes. Dichromats showed generally reduced VEP amplitudes. Responses to cone-specific stimuli obtained with standard electro-physiological methods may give the same classification as that obtained with the Cambridge Colour Test and in some cases with the genetic analysis of the L- and M-opsin genes. Therefore, cone-specific ERGS and VEPs may be reliable methods to detect cone dysfunction. The present data confirm and emphasize the potential use of cone specific stimulation, combined with standard visual electrodiagnostic protocols. (AU)

Processo FAPESP: 14/26818-2 - Desenvolvimento e implantação de métodos de avaliação visual: aplicações clínicas e em modelos animais
Beneficiário:Dora Selma Fix Ventura
Linha de fomento: Auxílio à Pesquisa - Temático
Processo FAPESP: 16/22007-5 - Optimização da capacidade funcional visual de pacientes com maculopatias através de protocolos de treinamento do sistema visual
Beneficiário:Mirella Telles Salgueiro Barboni
Linha de fomento: Bolsas no Exterior - Pesquisa
Processo FAPESP: 16/04538-3 - Distrofinas e o sistema visual humano: estudo dos diferentes fenótipos visuais de pacientes com Distrofia Muscular de Duchenne
Beneficiário:Dora Selma Fix Ventura
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 14/25743-9 - Expressão de opsinas e melanopsinas em retinas de serpentes: genética molecular e imunohistoquímica
Beneficiário:Einat Hauzman
Linha de fomento: Bolsas no Brasil - Pós-Doutorado