Patterning and Modeling Three-Dimensional Microfluidic Devices Fabricated on a Single Sheet of Paper

Autor(es)

Mora, Maria F. ^{[1, 2]} ; Garcia, Carlos D. ^[3] ; Schaumburg, Federico ^[4] ; Kler, Pablo A. ^[5] ; Berli, Claudio L. A. ^[4] ; Hashimoto, Michinao ^{[2, 6]} ; Carrilho, Emanuel ^{[7, 2]}

Afiliação do(s) autor(es)

^[1] CALTECH, Jet Prop Lab, 4800 Oak Grove Dr, Pasadena, CA 91109 - USA

^[2] Harvard Univ, Dept Chem & Chem Biol, 12 Oxford St, Cambridge, MA 02138 - USA

^[3] Clemson Univ, Dept Chem, Clemson, SC 29634 - USA

^[4] Univ Nacl Litoral, CONICET, INTEC, RA-3000 Santa Fe - Argentina

^[5] Univ Nacl Litoral, CONICET, CIMEC, RA-3000 Santa Fe - Argentina

^[6] Singapore Univ Technol & Design, Pillar Engn Prod Dev, Singapore 487372 - Singapore

^[7] Univ Sao Paulo, Inst Quim Sao Carlos, BR-13566590 Sao Carlos, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Analytical Chemistry; v. 91, n. 13, p. 8298-8303, JUL 2 2019.
• Citações Web of Science: 1

Resumo

This work describes a method to fabricate three-dimensional paper microfluidic devices in one step, without the need of stacking layers of paper, glue, or tape. We used a nontransparent negative photoresist that allows patterning selectively (vertically) the paper, creating systems of two or three layers, including channels. To demonstrate the capabilities of this methodology, we designed, fabricated, and tested a six-level diluter. The performance of the device was also simulated using a simple numerical model implemented in the program PETSc-FEM. The resulting mu PAD is small (1.6 cm x 2.2 cm), inexpensive, requires low volumes of sample (5 mu L), and is able to perform mixing and dilution in 2 min. (AU)

• Processo FAPESP: 06/02007-9 - Desenvolvimento de ferragens microfluídicas que permitam o desenho e fabricação de sistemas bioanalíticos para química biológica, bioquímica e medicina
• Beneficiário: Emanuel Carrilho
• Modalidade de apoio: Bolsas no Exterior - Novas Fronteiras