Patterning and Modeling Three-Dimensional Microfluidic Devices Fabricated on a Single Sheet of Paper

Author(s)

Mora, Maria F. ^{[1, 2]} ; Garcia, Carlos D. ^[3] ; Schaumburg, Federico ^[4] ; Kler, Pablo A. ^[5] ; Berli, Claudio L. A. ^[4] ; Hashimoto, Michinao ^{[2, 6]} ; Carrilho, Emanuel ^{[7, 2]}

Affiliation

^[1] CALTECH, Jet Prop Lab, 4800 Oak Grove Dr, Pasadena, CA 91109 - USA

^[2] Harvard Univ, Dept Chem & Chem Biol, 12 Oxford St, Cambridge, MA 02138 - USA

^[3] Clemson Univ, Dept Chem, Clemson, SC 29634 - USA

^[4] Univ Nacl Litoral, CONICET, INTEC, RA-3000 Santa Fe - Argentina

^[5] Univ Nacl Litoral, CONICET, CIMEC, RA-3000 Santa Fe - Argentina

^[6] Singapore Univ Technol & Design, Pillar Engn Prod Dev, Singapore 487372 - Singapore

^[7] Univ Sao Paulo, Inst Quim Sao Carlos, BR-13566590 Sao Carlos, SP - Brazil

• Document type: Journal article
• Source: Analytical Chemistry; v. 91, n. 13, p. 8298-8303, JUL 2 2019.
• Web of Science Citations: 1

Abstract

This work describes a method to fabricate three-dimensional paper microfluidic devices in one step, without the need of stacking layers of paper, glue, or tape. We used a nontransparent negative photoresist that allows patterning selectively (vertically) the paper, creating systems of two or three layers, including channels. To demonstrate the capabilities of this methodology, we designed, fabricated, and tested a six-level diluter. The performance of the device was also simulated using a simple numerical model implemented in the program PETSc-FEM. The resulting mu PAD is small (1.6 cm x 2.2 cm), inexpensive, requires low volumes of sample (5 mu L), and is able to perform mixing and dilution in 2 min. (AU)