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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Microbiota-derived acetate protects against respiratory syncytial virus infection through a GPR43-type 1 interferon response

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Autor(es):
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Antunes, Krist Helen [1] ; Fachi, Jose Luis [2] ; de Paula, Rosemeire [2] ; da Silva, Emanuelle Fraga [1] ; Pral, Lais Passariello [2] ; dos Santos, Adara Aurea [3] ; Malaquias Dias, Greicy Brisa [3] ; Vargas, Jose Eduardo [4] ; Puga, Renato [5] ; Mayer, Fabiana Quoos [6] ; Maito, Fabio [7] ; Zarate-Blades, Carlos R. [8] ; Ajami, Nadim J. [9] ; St Ana, Marcella Ramos [10] ; Candreva, Thamiris [11] ; Rodrigues, Hosana Gomes [11] ; Schmiele, Marcio [12] ; Pedrosa Silva Clerici, Maria Teresa [13] ; Proenca-Modena, Jose Luiz [14] ; Vieira, Angelica Thomas [15] ; Mackay, Charles R. [16] ; Mansur, Daniel [3] ; Caballero, Mauricio T. [17] ; Marzec, Jacqui [18] ; Li, Jianying [18] ; Wang, Xuting [18] ; Bell, Douglas [18] ; Polack, Fernando P. [17, 19] ; Kleeberger, Steven R. [18] ; Stein, Renato T. [20] ; Ramirez Vinolo, Marco Aurelio [2] ; Duarte de Souza, Ana Paula [1, 21]
Número total de Autores: 32
Afiliação do(s) autor(es):
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[1] Pontificia Univ Catolica Rio Grande do Sul, Sch Med, Lab Clin & Expt Immunol, Infant Ctr, BR-90610000 Porto Alegre, RS - Brazil
[2] Univ Estadual Campinas, Inst Biol, Dept Genet Evolut Microbiol & Immunol, Lab Immunoinflammat, BR-13083007 Campinas, SP - Brazil
[3] Univ Fed Santa Catarina, Ctr Ciencias Biol, Dept Microbiol Immunol & Parasitol, Lab Imunobiol, BR-88040900 Florianopolis, SC - Brazil
[4] Univ Passo Fundo, Biol Sci Inst ICB, BR-99052900 Passo Fundo, RS - Brazil
[5] HIAE, Clin Res Ctr, BR-05652900 Sao Paulo - Brazil
[6] Secretariat Agr Livestock & Irrigat, Agr Diag & Res Dept, Vet Res Inst Desiderio Finamor, Mol Biol Lab, BR-92990000 Eldorado Do Sul, RS - Brazil
[7] Pontificia Univ Catolica Rio Grande do Sul, Hlth Sci Sch, Lab Pathol, BR-90610000 Porto Alegre, RS - Brazil
[8] Univ Fed Santa Catarina, UFSC, Dept Microbiol Immunol & Parasitol, Lab Limmunoregulat, BR-8804900 Florianopolis, SC - Brazil
[9] Baylor Coll Med, Dept Mol Virol & Microbiol, Alkek Ctr Metagen & Microbiome Res, Houston, TX 77030 - USA
[10] Univ Estadual Campinas, Sch Appl Sci, Lab Nutr Genom, BR-13484350 Limeira, SP - Brazil
[11] Univ Estadual Campinas, Sch Appl Sci, Lab Nutrients & Tissue Repair, BR-13484350 Limeira, SP - Brazil
[12] Fed Univ Jequitinhonha & Mucuri Valleys UFVJM, Inst Sci & Technol, BR-39803371 Teofilo Otoni, MG - Brazil
[13] Univ Estadual Campinas, UNICAMP, Sch Food Engn, Dept Food Technol, Monteiro Lobato 80, BR-13083970 Campinas, SP - Brazil
[14] Univ Estadual Campinas, Inst Biol, Dept Genet Evolut Microbiol & Immunol, Emerging Viruses Study Lab, BR-13083970 Campinas, SP - Brazil
[15] Univ Fed Minas Gerais, Dept Biochem & Immunol, BR-31270901 Belo Horizonte, MG - Brazil
[16] Monash Univ, Biodiscovery Res Inst, Clayton, Vic 3800 - Australia
[17] Fdn INFANT, RA-1406 Buenos Aires, DF - Argentina
[18] NIEHS, NIH, Durham, NC 27709 - USA
[19] Vanderbilt Univ, EUA, Nashville, TN 37240 - USA
[20] Sao Lucas Hosp PUCRS, Dept Pediat, Sch Med, Infant Ctr, BR-90610000 Porto Alegre, RS - Brazil
[21] Pontificia Univ Catolica Rio Grande do Sul, Sch Heath Sci, BR-90610000 Porto Alegre, RS - Brazil
Número total de Afiliações: 21
Tipo de documento: Artigo Científico
Fonte: NATURE COMMUNICATIONS; v. 10, JUL 22 2019.
Citações Web of Science: 1
Resumo

Severe respiratory syncytial virus (RSV) infection is a major cause of morbidity and mortality in infants <2 years-old. Here we describe that high-fiber diet protects mice from RSV infection. This effect was dependent on intestinal microbiota and production of acetate. Oral administration of acetate mediated interferon-beta (IFN-beta) response by increasing expression of interferon-stimulated genes in the lung. These effects were associated with reduction of viral load and pulmonary inflammation in RSV-infected mice. Type 1 IFN signaling via the IFN-1 receptor (IFNAR) was essential for acetate antiviral activity in pulmonary epithelial cell lines and for the acetate protective effect in RSV-infected mice. Activation of Gpr43 in pulmonary epithelial cells reduced virus-induced cytotoxicity and promoted antiviral effects through IFN-beta response. The effect of acetate on RSV infection was abolished in Gpr43(-/-) mice. Our findings reveal antiviral effects of acetate involving IFN-beta in lung epithelial cells and engagement of GPR43 and IFNAR. (AU)

Processo FAPESP: 17/06577-9 - Mecanismos envolvidos no efeito protetor dos ácidos graxos de cadeia curta frente à colite associada ao Clostridium difficile
Beneficiário:José Luís Fachi
Linha de fomento: Bolsas no Brasil - Doutorado
Processo FAPESP: 13/06810-4 - Mecanismos de ação dos ácidos graxos ômega-3 e ômega-6 no processo de reparo tecidual: enfoque neuro-imunológico
Beneficiário:Hosana Gomes Rodrigues
Linha de fomento: Auxílio à Pesquisa - Apoio a Jovens Pesquisadores
Processo FAPESP: 12/10653-9 - Envolvimento dos ácidos graxos de cadeia curta e seu receptor (GPR43) na resposta imune a bactérias anaeróbias in vivo e in vitro
Beneficiário:Marco Aurélio Ramirez Vinolo
Linha de fomento: Auxílio à Pesquisa - Apoio a Jovens Pesquisadores