Melatonin Signaling a Key Regulator of Glucose Homeostasis and Energy Metabolism

Autor(es)

Owino, Sharon ^{[1, 2]} ; Buonfiglio, Daniella D. C. ^{[3, 1]} ; Tchio, Cynthia ^[1] ; Tosini, Gianluca ^[1]

Afiliação do(s) autor(es)

^[1] Morehouse Sch Med, Neurosci Inst, Dept Pharmacol & Toxicol, Atlanta, GA 30310 - USA

^[2] Emory Univ, Sch Med, Dept Pharmacol, Atlanta, GA 30322 - USA

^[3] Univ Sao Paulo, Inst Biomed Sci 1, Dept Physiol & Biophys, Sao Paulo - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: FRONTIERS IN ENDOCRINOLOGY; v. 10, JUL 17 2019.
• Citações Web of Science: 1

Resumo

Melatonin, a hormone synthesized by both the pineal gland and retina, functions as an important modulator of a number of physiological functions. In addition to its rather well-established roles in the regulation of circadian rhythms, sleep, and reproduction, melatonin has also been identified as an important regulator of glucose metabolism. Recent genomic studies have also shown that disruption of melatonin receptors signaling may contribute to the pathogenesis of type 2 diabetes, although the exact mechanisms underlying its action remain unclear. Additionally, a large number of animal studies have highlighted a role for melatonin in the regulation of both glucose metabolism and energy balance. This review summarizes the current knowledge on the role that melatonin and its associated receptors play in the regulation of metabolism. (AU)

• Processo FAPESP: 17/01882-8 - O papel dos receptores de melatonina no consumo alimentar, balanço energético e na via de sinalização da leptina
• Beneficiário: Daniella Do Carmo Buonfiglio
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Pós-Doutorado