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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Melatonin Signaling a Key Regulator of Glucose Homeostasis and Energy Metabolism

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Author(s):
Owino, Sharon [1, 2] ; Buonfiglio, Daniella D. C. [3, 1] ; Tchio, Cynthia [1] ; Tosini, Gianluca [1]
Total Authors: 4
Affiliation:
[1] Morehouse Sch Med, Neurosci Inst, Dept Pharmacol & Toxicol, Atlanta, GA 30310 - USA
[2] Emory Univ, Sch Med, Dept Pharmacol, Atlanta, GA 30322 - USA
[3] Univ Sao Paulo, Inst Biomed Sci 1, Dept Physiol & Biophys, Sao Paulo - Brazil
Total Affiliations: 3
Document type: Review article
Source: FRONTIERS IN ENDOCRINOLOGY; v. 10, JUL 17 2019.
Web of Science Citations: 1
Abstract

Melatonin, a hormone synthesized by both the pineal gland and retina, functions as an important modulator of a number of physiological functions. In addition to its rather well-established roles in the regulation of circadian rhythms, sleep, and reproduction, melatonin has also been identified as an important regulator of glucose metabolism. Recent genomic studies have also shown that disruption of melatonin receptors signaling may contribute to the pathogenesis of type 2 diabetes, although the exact mechanisms underlying its action remain unclear. Additionally, a large number of animal studies have highlighted a role for melatonin in the regulation of both glucose metabolism and energy balance. This review summarizes the current knowledge on the role that melatonin and its associated receptors play in the regulation of metabolism. (AU)

FAPESP's process: 17/01882-8 - The central role of melatonin receptors on food intake, energy balance and leptin pathway
Grantee:Daniella Do Carmo Buonfiglio
Support Opportunities: Scholarships abroad - Research Internship - Post-doctor