Systemic expression of genes related to inflammation and lipid metabolism in patients with dyslipidemia, type 2 diabetes mellitus and chronic periodontitis

Autor(es)

Nepomuceno, Rafael ^{[1, 2]} ; Vallerini, Bruna de E. ^[1] ; da Silva, Romerito L. ^[2] ; Corbi, Sarnia C. T. ^{[1, 2]} ; Bastos, Alliny de S. ^[2] ; dos Santos, Raquel A. ^[3] ; Takahashi, Catarina S. ^{[4, 5]} ; Orrico, Silvana Regina P. ^[2] ; Scarel-Caminaga, Raquel M. ^[1]

Afiliação do(s) autor(es)

^[1] UNESP Sao Paulo State Univ, Sch Dent Araraquara, Dept Morphol, CP 331, BR-14801903 Araraquara, SP - Brazil

^[2] UNESP Sao Paulo State Univ, Sch Dent Araraquara, Dept Diag & Surg, BR-14801903 Araraquara, SP - Brazil

^[3] Univ Franca, Postgrad Program Sci, BR-14404600 Franca, SP - Brazil

^[4] Univ Sao Paulo, FFCLRP, Fac Med Ribeirao Preto, Dept Genet, BR-14040900 Ribeirao Preto, SP - Brazil

^[5] Univ Sao Paulo, FFCLRP, Dept Biol, BR-14040900 Ribeirao Preto, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS; v. 13, n. 4, p. 2715-2722, JUL-AUG 2019.
• Citações Web of Science: 1

Resumo

Inflammatory diseases, as periodontal disease (PD), has been associated with disturbance of lipid and glycemic metabolisms, as demonstrated by the increasing of PD patients with type 2 diabetes mellitus (T2D) and/or dyslipidemia comorbidities. We aimed to investigate the expression of inflammation and lipid metabolism genes, and correlations among clinical and biochemical characteristics in normoglycemic or T2D patients with dyslipidemia and PD, in comparison with healthy individuals. Five groups of 30 individuals each (150 patients) were formed based upon T2D, dyslipidemic and periodontal status. Blood analyses of lipid and glycemic profiles were carried out, and the gene expression was assessed by RT-qPCR. The systemic expression of 1L6, TNFA and LEP genes were significantly higher in T2D, dyslipidemia and PD patients, while the PECAM1 gene showed the opposite. Higher RETN levels were found in patients with T2D independently of their glycemic control status. There were positive correlations between: TNFA, LEP and RETN with worse periodontal parameters; 1L6, TNFA, ADIPOR1, LEP and RETN with waist-to-hip ratio; glycemic parameters with RETN; total cholesterol and triglycerides with LEP expression. We conclude that pro-inflammatory cytokines were related with worse lipid, glycemic and periodontal parameters, reinforcing that a hyper-inflammatory status connects systemic and oral inflammatory diseases. (C) 2019 Diabetes India. Published by Elsevier Ltd. All rights reserved. (AU)

• Processo FAPESP: 14/19699-7 - Expressão dos genes IL6 e TNFA em indivíduos com Diabetes Mellitus tipo 2, Dislipidemia e Doença Periodontal
• Beneficiário: Bruna de Freitas Vallerini
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 07/08362-8 - Avaliação da correlação entre peroxidação lipídica e o perfil de marcadores inflamatórios em pacientes portadores de diabetes mellitus tipo 2 com periodontite crônica
• Beneficiário: Silvana Regina Perez Orrico
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 09/16233-9 - Avaliação do efeito da descompensação do Diabetes Mellitus sobre a expressão de genes do sistema imune e sobre lesões no DNA em pacientes com periodontite crônica.
• Beneficiário: Sâmia Cruz Tfaile Corbi
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 10/10882-2 - Expressão gênica em indivíduos portadores de Diabetes mellitus tipo 2, dislipidemia e doença periodontal: avaliação por microarray
• Beneficiário: Raquel Mantuaneli Scarel Caminaga
• Modalidade de apoio: Auxílio à Pesquisa - Regular