Temporal evolution of antimicrobial resistance among Neisseria gonorrhoeae clinical isolates in the most populated South American Metropolitan Region

Autor(es):Mostrar menos -

Martins, Rafael Affini ^[1] ; Cassu-Corsi, Dandara ^[1] ; Nodari, Carolina Silva ^[1] ; Cayo, Rodrigo ^{[1, 2]} ; Natsumeda, Larissa ^[1] ; Streling, Ana Paula ^[1] ; Doi, Andre Mario ^[3] ; Carvalho da Silva, Roberto Jose ^[4] ; Lima Bocalon, Roberta Alessandra ^[4] ; Gales, Ana Cristina ^{[1, 3]} ; Campos Pignatari, Antonio Carlos ^{[1, 3]}

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo, Escola Paulista Med, Dept Med, Lab ALERTA, Sao Paulo, SP - Brazil

^[2] Univ Fed Sao Paulo, Inst Ciencias Ambientais Quim & Farmaceut, Dept Ciencias Biol, Lab Bacteriol & Imunol, Diadema, SP - Brazil

^[3] Univ Fed Sao Paulo, Escola Paulista Med, Dept Med, Lab Especial Microbiol Clin, Sao Paulo, SP - Brazil

^[4] Ctr Referencia & Tratamento Doencas Sexualmente T, Sao Paulo, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Memórias do Instituto Oswaldo Cruz; v. 114, 2019.
• Citações Web of Science: 0

Resumo

A total of 124 Neisseria gonorrhoeae isolates recovered during a 12-year period (2003-2015) from outpatients assisted at Centro de Referência e Treinamento DST/AIDS-CRT of São Paulo city, Brazil, were analysed. The following resistance rates were observed: penicillin-59.6%, ciprofloxacin-15.3%, and azithromycin-6.7%. Although reduced susceptibility to these drugs was observed since 2003, no ceftriaxone-resistant isolates were detected. Ciprofloxacin- and azithromycin non-susceptible isolates were grouped in 11 clusters. Mutations were detected in GyrA and ParC of isolates 124 and 260, and a C2611T substitution on 23S rRNA alleles was also observed in isolate 260. Both isolates belonged to ST1901/ST6210 (MSLT/NG-MAST schemes). (AU)

• Processo FAPESP: 16/01889-0 - Avaliação do perfil de sensibilidade aos antimicrobianos, mecanismos de resistência e caracterização genotípica de isolados de Neisseria gonorrhoeae na cidade de São Paulo - Brasil
• Beneficiário: Antonio Carlos Campos Pignatari
• Modalidade de apoio: Auxílio à Pesquisa - Regular