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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Temporal evolution of antimicrobial resistance among Neisseria gonorrhoeae clinical isolates in the most populated South American Metropolitan Region

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Author(s):
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Martins, Rafael Affini [1] ; Cassu-Corsi, Dandara [1] ; Nodari, Carolina Silva [1] ; Cayo, Rodrigo [1, 2] ; Natsumeda, Larissa [1] ; Streling, Ana Paula [1] ; Doi, Andre Mario [3] ; Carvalho da Silva, Roberto Jose [4] ; Lima Bocalon, Roberta Alessandra [4] ; Gales, Ana Cristina [1, 3] ; Campos Pignatari, Antonio Carlos [1, 3]
Total Authors: 11
Affiliation:
[1] Univ Fed Sao Paulo, Escola Paulista Med, Dept Med, Lab ALERTA, Sao Paulo, SP - Brazil
[2] Univ Fed Sao Paulo, Inst Ciencias Ambientais Quim & Farmaceut, Dept Ciencias Biol, Lab Bacteriol & Imunol, Diadema, SP - Brazil
[3] Univ Fed Sao Paulo, Escola Paulista Med, Dept Med, Lab Especial Microbiol Clin, Sao Paulo, SP - Brazil
[4] Ctr Referencia & Tratamento Doencas Sexualmente T, Sao Paulo, SP - Brazil
Total Affiliations: 4
Document type: Journal article
Source: Memórias do Instituto Oswaldo Cruz; v. 114, 2019.
Web of Science Citations: 0
Abstract

A total of 124 Neisseria gonorrhoeae isolates recovered during a 12-year period (2003-2015) from outpatients assisted at Centro de Referência e Treinamento DST/AIDS-CRT of São Paulo city, Brazil, were analysed. The following resistance rates were observed: penicillin-59.6%, ciprofloxacin-15.3%, and azithromycin-6.7%. Although reduced susceptibility to these drugs was observed since 2003, no ceftriaxone-resistant isolates were detected. Ciprofloxacin- and azithromycin non-susceptible isolates were grouped in 11 clusters. Mutations were detected in GyrA and ParC of isolates 124 and 260, and a C2611T substitution on 23S rRNA alleles was also observed in isolate 260. Both isolates belonged to ST1901/ST6210 (MSLT/NG-MAST schemes). (AU)

FAPESP's process: 16/01889-0 - Evaluation of antimicrobial susceptibility profile, resistance mechanisms and genotypic characterization of Neisseria gonorrhoeae isolated in São Paulo - Brazil
Grantee:Antonio Carlos Campos Pignatari
Support Opportunities: Regular Research Grants