Amygdala and Hypothalamus: Historical Overview With Focus on Aggression

Autor(es)

Gouveia, Flavia Venetucci ^[1] ; Hamani, Clement ^{[2, 3]} ; Fonoff, Erich Talamoni ^[3] ; Brentani, Helena ^{[4, 5]} ; Lopes Alho, Eduardo Joaquim ^[3] ; Campelo Borba de Morais, Rosa Magaly ^[6] ; de Souza, Aline Luz ^[3] ; Rigonatti, Sergio Paulo ^[5] ; Martinez, Raquel C. R. ^[1]

Afiliação do(s) autor(es)

^[1] Hosp Sirio Libanes, Lab Neurosci, Sao Paulo - Brazil

^[2] Univ Toronto, Sunnybrook Hlth Sci Ctr, Div Neurosurg, Toronto, ON - Canada

^[3] Univ Sao Paulo Sch, Med Sch, Inst Psychiat, Dept Neurol, Div Funct Neurosurg, Sao Paulo - Brazil

^[4] CNPq, Natl Inst Dev Psychiat Children & Adolescents, Sao Paulo - Brazil

^[5] Univ Sao Paulo, Med Sch, Dept Psychiat, Sao Paulo - Brazil

^[6] Univ Sao Paulo, Dept Psychiat, PROTEA, Sch Med, Sao Paulo - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: NEUROSURGERY; v. 85, n. 1, p. 11-30, JUL 2019.
• Citações Web of Science: 1

Resumo

Aggressiveness has a high prevalence in psychiatric patients and is a major health problem. Two brain areas involved in the neural network of aggressive behavior are the amygdala and the hypothalamus. While pharmacological treatments are effective in most patients, some do not properly respond to conventional therapies and are considered medically refractory. In this population, surgical procedures (ie, stereotactic lesions and deep brain stimulation) have been performed in an attempt to improve symptomatology and quality of life. Clinical results obtained after surgery are difficult to interpret, and the mechanisms responsible for postoperative reductions in aggressive behavior are unknown. We review the rationale and neurobiological characteristics that may help to explain why functional neurosurgery has been proposed to control aggressive behavior. (AU)

• Processo FAPESP: 13/20602-5 - Análise prospectiva dos resultados funcionais da amigdalotomia bilateral assistencial em pacientes com agressividade refratária
• Beneficiário: Flavia Venetucci Gouveia
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 17/10466-8 - Desvendando agressividade: estudo de imagem do cérebro agressivo
• Beneficiário: Flavia Venetucci Gouveia
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Doutorado
• Processo FAPESP: 11/08575-7 - Papel da modulação dopaminérgica no núcleo lateral da amígdala sobre a resposta condicionada de esquiva
• Beneficiário: Raquel Chacon Ruiz Martinez
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores