X-Ray Characterization of Pharmaceutical and Cosmetic Lipidic Nanoparticles for Cutaneous Application

Autor(es)

Carducci, Federica ^[1] ; Casadei, Bruna Renata ^[2] ; Mariani, Paolo ^[1] ; Barbosa, Leandro Ramos Souza ^[2]

Afiliação do(s) autor(es)

^[1] Univ Politecn Marche, Dipartimento Sci Vita & Ambiente, Ancona - Italy

^[2] Univ Sao Paulo, Dept Fis Geral, Inst Fis, Sao Paulo - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: CURRENT PHARMACEUTICAL DESIGN; v. 25, n. 21, p. 2364-2374, 2019.
• Citações Web of Science: 2

Resumo

Starting from the second half of the 1900s, the advent of nanotechnology in medicine has provoked a profound revolution in this area; at present, nanomedicine delivered a remarkably large set of research and clinically useful tools as diagnostic devices, contrast agents, analytical tools, physical therapy applications, and drug-delivery vehicles. Concerning nanoformulations for drug delivery, they are constituted by nanoparticles with dimensions lower than 1 mu m, usually characterized by improved pharmacokinetics, taking advantage of specific targeting. and reduced side effects. The contributors to the present chapter arc reviewing a range of papers related to the structural characterization of nanoformulations by X-ray diffraction techniques. The whole of the considered papers underlines the essential role that biophysical techniques have acquired as an essential prerequisite to understanding stability, bioavailability, and lipid, biopolymer, and drug organization in nanoformulations. (AU)

• Processo FAPESP: 15/15822-1 - Estudo das propriedades físico-químicas e estruturais de fármacos e líquidos iônicos com sistemas de relevância biológica
• Beneficiário: Leandro Ramos Souza Barbosa
• Modalidade de apoio: Auxílio à Pesquisa - Regular