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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Therapeutic treatment with Modafinil decreases the severity of experimental autoimmune encephalomyelitis in mice

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Autor(es):
Brandao, Wesley Nogueira [1] ; Andersen, Monica Levy [2] ; Palermo-Neto, Joao [3] ; Peron, Jean Pierre [1] ; Zager, Adriano [3, 4]
Número total de Autores: 5
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Inst Biomed Sci, Dept Immunol, Neuroimmune Interact Lab, Sao Paulo - Brazil
[2] Fed Univ Sao Paulo UNIFESP EPM, Dept Psychobiol, Sao Paulo - Brazil
[3] Univ Sao Paulo, Sch Vet Med, Dept Pathol, Neuroimmunomodulat Res Grp, Sao Paulo - Brazil
[4] Linkoping Univ, Fac Med & Hlth Sci, Dept Clin & Expt Med, Div Neurobiol, S-58185 Linkoping - Sweden
Número total de Afiliações: 4
Tipo de documento: Artigo Científico
Fonte: International Immunopharmacology; v. 75, OCT 2019.
Citações Web of Science: 0
Resumo

The psychostimulant drug modafinil has been used for many years for the treatment of sleep disorders. Recent studies have indicated that modafinil has immunomodulatory properties in the central nervous system (CNS) and peripheral immune cells. Thus, our aim was to determine the effects of in vivo therapeutic treatment with modafinil on the severity of clinical symptoms and immune response during the acute phase of experimental autoimmune encephalomyelitis (EAE), an experimental model of multiple sclerosis. Modafinil treatment, given after the onset of symptoms, resulted in an improvement of EAE symptoms and motor impairment, which was correlated with reduced cellular infiltrate and a decreased percentage of T helper (Th) 1 cells in the CNS. The spinal cord analysis revealed that modafinil treatment decreased interferon (IFN)-y and interleukin (IL)-6 protein levels and down regulated genes related to Th1 immunity, such as IFN-gamma and TBX21, without affecting Th17-related genes. Our research indicates that therapeutic modafinil treatment has anti-inflammatory properties in an EAE model by inhibiting brain Th1 response, and may be useful as adjuvant treatment for multiple sclerosis. (AU)

Processo FAPESP: 17/26170-0 - Neuroimunobiologia em modelo experimental de Encefalomielite Autoimune e Síndrome Congênita do Zika Vírus: fisiopatogenia, susceptibilidade, terapia celular, vacinação
Beneficiário:Jean Pierre Schatzmann Peron
Linha de fomento: Auxílio à Pesquisa - Temático
Processo FAPESP: 13/18921-5 - Avaliação do efeito do modafinil sobre a imunidade, neuroinflamação e desenvolvimento da encefalomielite autoimune experimental em camundongos
Beneficiário:Adriano Zager
Linha de fomento: Bolsas no Brasil - Pós-Doutorado
Processo FAPESP: 11/18703-2 - O papel do eixo triptofano - Kinureninas na regulação da resposta imune através de receptores de glutamato tipo NMDA na encefalomielite experimental auto-imune e na lesão por isquemia e reperfusão cerebral
Beneficiário:Jean Pierre Schatzmann Peron
Linha de fomento: Auxílio à Pesquisa - Apoio a Jovens Pesquisadores