N-Myristoyltransferases as antileishmanial targets: a piggyback approach with benzoheterocyclic analogues

Autor(es)

Luis Otávio Junqueira ^[1] ; Marcela Oliveira Legramanti da Costa ^[2] ; Daniela Gonçales Galasse Rando ^[3]

Afiliação do(s) autor(es)

^[1] Universidade Federal de São Paulo. Instituto de Ciências Ambientais, Químicas e Farmacêuticas. Departamento de Ciências Farmacêuticas - Brasil

^[2] Universidade Federal de São Paulo. Instituto de Ciências Ambientais, Químicas e Farmacêuticas. Departamento de Ciências Farmacêuticas - Brasil

^[3] Universidade Federal de São Paulo. Instituto de Ciências Ambientais, Químicas e Farmacêuticas. Departamento de Ciências Farmacêuticas - Brasil

• Tipo de documento: Artigo Científico
• Fonte: Brazilian Journal of Pharmaceutical Sciences; v. 55, 2019-10-24.

Resumo

Leishmaniasis is one of the neglected diseases that remain in need for pharmacological alternatives. In this context, N-Myristoyltransferases (NMT) arise as interesting targets to explore since they are involved in the co/post-translational processing of peptides which are responsible for host cell invasion. Studies that consider these enzymes as targets point out the potential of benzoheterocyclic compounds as inhibitors of Candida albicans’s N-myristoyltransferase. Here we applied a combination of comparative binding site analysis and molecular docking studies based on a Piggyback approach in the search for new Leishmania major NMT ligands. Our results revealed that NMT enzymes from both pathogens present enough structural similarity to allow extrapolation of the knowledge available from C. albicans studies to develop new L. major NMT inhibitors. Molecular docking studies with benzoheterocyclic analogues indicate the potential of benzothiazole derivatives as L. major NMT ligands, giving rise to a completely new class of chemical compounds to be explored in the development of antileishmanial drugs. (AU)

• Processo FAPESP: 13/01875-0 - Síntese paralela, screening in vitro e estudos de relação estrutura-atividade de nitroderivados ativos contra patógenos infectantes de macrófagos: Mycobacterium tuberculosis formas NRP e Leishmania sp
• Beneficiário: Daniela Goncales Galasse Rando
• Modalidade de apoio: Auxílio à Pesquisa - Regular