Effects of Maternal Psychopathology and Education Level on Neurocognitive Development in Infants of Adolescent Mothers Living in Poverty in Brazil

Autor(es):Mostrar menos -

Shephard, Elizabeth ^{[1, 2]} ; Fatori, Daniel ^[1] ; Mauro, Larissa Rezende ^[1] ; de Medeiros Filho, V, Mauro ; Hoexter, Marcelo Q. ^[3] ; Chiesa, Anna M. ^[4] ; Fracolli, Lislaine A. ^[4] ; Brentani, Helena ^[3] ; Ferraro, Alexandre A. ^[3] ; Nelson, III, Charles A. ; Miguel, Euripedes C. ^[3] ; Polanczyk, V, Guilherme

Afiliação do(s) autor(es)

^[1] V, Univ Sao Paulo, Fac Med, Dept Psychiat, Sao Paulo - Brazil

^[2] Kings Coll London, Inst Psychiat Psychol & Neurosci, London SE5 8AF - England

^[3] de Medeiros Filho, Mauro, V, V, Univ Sao Paulo, Fac Med, Dept Psychiat, Sao Paulo - Brazil

^[4] Univ Sao Paulo, Sch Nursing, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING; v. 4, n. 10, p. 925-934, OCT 2019.
• Citações Web of Science: 0

Resumo

BACKGROUND: Adolescent motherhood remains common in developing countries and is associated with risk factors that adversely impact infant neurodevelopment, including poverty, low maternal education, and increased maternal psychopathology. Yet, no published work has assessed how these factors affect early brain development in developing countries. METHODS: This pilot study examined effects of maternal psychopathology and education on early neurocognitive development in a sample of adolescent mothers (N = 50, final n = 31) and their infants living in poverty in Sao Paulo, Brazil. Maternal symptoms of anxiety, depression, and attention-deficit/hyperactivity disorder and education level were assessed during pregnancy. Infant neurocognitive development was assessed at 6 months of age, with oscillatory power and functional connectivity in the theta (4-6 Hz), alpha (6-9 Hz), and gamma (30-50 Hz) frequencies derived from resting-state electroencephalography; temperament (negative affect, attention, and regulation); and cognitive, language, and motor skills. Cluster-based permutation testing and graph-theoretical methods were used to identify alterations in oscillatory power and connectivity that were associated with maternal psychopathology and education. Correlations between power and connectivity alterations were examined in relation to infants' overt cognitive behavioral abilities. RESULTS: Increased maternal anxiety and lower maternal education were associated with weaker oscillatory connectivity in alpha-range networks. Infants with the weakest connectivity in the alpha network associated with maternal anxiety also showed the lowest cognitive ability. Greater maternal anxiety and attention-deficit/hyperactivity disorder were associated with increased absolute and relative theta power. CONCLUSIONS: Our findings highlight the importance of addressing maternal psychopathology and improving education in poor adolescent mothers to prevent negative effects on infant neurodevelopment. (AU)

• Processo FAPESP: 16/22455-8 - Intervenções na primeira infância e trajetórias de desenvolvimento cognitivo, social e emocional
• Beneficiário: Guilherme Vanoni Polanczyk
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 17/17718-2 - Os efeitos de intervenções psicossociais e sintomas neuropsiquiátricos no funcionamento social e nas redes neurais em crianças, adolescentes e jovens brasileiros
• Beneficiário: Eurípedes Constantino Miguel Filho
• Modalidade de apoio: Auxílio à Pesquisa - Pesquisador Visitante - Internacional