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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Unraveling genomic associations with feed efficiency and body weight traits in chickens through an integrative approach

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Autor(es):
Monteiro Moreira, Gabriel Costa [1] ; Poleti, Mirele Daiana [2] ; Pertille, Fabio [1] ; Boschiero, Clarissa [1] ; Mello Cesar, Aline Silva [1] ; Godoy, Thais Fernanda [1] ; Ledur, Monica Correa [3] ; Reecy, James M. [4] ; Garrick, Dorian J. [5] ; Coutinho, Luiz Lehmann [1]
Número total de Autores: 10
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Dept Anim Sci, BR-13418900 Piracicaba, SP - Brazil
[2] Univ Sao Paulo, Coll Anim Sci & Food Engn FZEA, Pirassununga, SP - Brazil
[3] Embrapa Suinos & Aves, Concordia, SC - Brazil
[4] ISU, Dept Anim Sci, Ames, IA - USA
[5] Massey Univ, Sch Agr, Hamilton - New Zealand
Número total de Afiliações: 5
Tipo de documento: Artigo Científico
Fonte: BMC GENETICS; v. 20, n. 1 NOV 6 2019.
Citações Web of Science: 0
Resumo

Background Feed efficiency and growth rate have been targets for selection to improve chicken production. The incorporation of genomic tools may help to accelerate selection. We genotyped 529 individuals using a high-density SNP chip (600 K, Affymetrix (R)) to estimate genomic heritability of performance traits and to identify genomic regions and their positional candidate genes associated with performance traits in a Brazilian F-2 Chicken Resource population. Regions exhibiting selection signatures and a SNP dataset from resequencing were integrated with the genomic regions identified using the chip to refine the list of positional candidate genes and identify potential causative mutations. Results Feed intake (FI), feed conversion ratio (FC), feed efficiency (FE) and weight gain (WG) exhibited low genomic heritability values (i.e. from 0.0002 to 0.13), while body weight at hatch (BW1), 35 days-of-age (BW35), and 41 days-of-age (BW41) exhibited high genomic heritability values (i.e. from 0.60 to 0.73) in this F-2 population. Twenty unique 1-Mb genomic windows were associated with BW1, BW35 or BW41, located on GGA1-4, 6-7, 10, 14, 24, 27 and 28. Thirty-eight positional candidate genes were identified within these windows, and three of them overlapped with selection signature regions. Thirteen predicted deleterious and three high impact sequence SNPs in these QTL regions were annotated in 11 positional candidate genes related to osteogenesis, skeletal muscle development, growth, energy metabolism and lipid metabolism, which may be associated with body weight in chickens. Conclusions The use of a high-density SNP array to identify QTL which were integrated with whole genome sequence signatures of selection allowed the identification of candidate genes and candidate causal variants. One novel QTL was detected providing additional information to understand the genetic architecture of body weight traits. We identified QTL for body weight traits, which were also associated with fatness in the same population. Our findings form a basis for further functional studies to elucidate the role of specific genes in regulating body weight and fat deposition in chickens, generating useful information for poultry breeding programs. (AU)

Processo FAPESP: 14/21380-9 - Estudo de associação ampla do genoma para deposição de gordura e rendimento de carcaça em galinhas
Beneficiário:Gabriel Costa Monteiro Moreira
Linha de fomento: Bolsas no Brasil - Doutorado
Processo FAPESP: 16/20440-3 - Análise epigenética de perfil de metilação em frangos submetidos à condições de estresse no ambiente de produção
Beneficiário:Fábio Pértille
Linha de fomento: Bolsas no Brasil - Pós-Doutorado
Processo FAPESP: 16/00569-1 - Imputação e associação genômica ampla utilizando haplótipos para gordura abdominal em galinhas
Beneficiário:Gabriel Costa Monteiro Moreira
Linha de fomento: Bolsas no Exterior - Estágio de Pesquisa - Doutorado
Processo FAPESP: 14/08704-0 - Identificação de locos de interesse zootécnico na galinha doméstica
Beneficiário:Luiz Lehmann Coutinho
Linha de fomento: Auxílio à Pesquisa - Temático
Processo FAPESP: 15/00616-7 - Identificação e caracterização de CNVs no genoma da galinha e associação com desenvolvimento de músculo de peito
Beneficiário:Thaís Fernanda Godoy
Linha de fomento: Bolsas no Brasil - Doutorado