Reduced melatonin synthesis in pregnant night workers: Metabolic implications for offspring

Autor(es)

Nehme, P. A. ^[1] ; Amaral, F. ^[2] ; Lowden, A. ^[3] ; Skene, D. J. ^[4] ; Cipolla-Neto, J. ^{[5, 6]} ; Moreno, C. R. C. ^{[1, 3]}

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Publ Hlth, Sao Paulo - Brazil

^[2] Univ Fed Sao Paulo, Dept Physiol, Sao Paulo - Brazil

^[3] Univ Stockholm, Stress Res Inst, Stockholm - Sweden

^[4] Univ Surrey, Fac Hlth & Med Sci, Guildford, Surrey - England

^[5] Univ Sao Paulo, Inst Biomed Sci, Dept Physiol, Sao Paulo - Brazil

^[6] Univ Sao Paulo, Inst Biomed Sci, Biophys Neurobiol Lab, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Medical Hypotheses; v. 132, NOV 2019.
• Citações Web of Science: 0

Resumo

Several novel animal studies have shown that intrauterine metabolic programming can be modified in the event of reduced melatonin synthesis during pregnancy, leading to glucose intolerance and insulin resistance in the offspring. It is therefore postulated that female night workers when pregnant may expose the offspring to unwanted health threats. This may be explained by the fact that melatonin is essential for regulating energy metabolism and can influence reproductive activity. Moreover, the circadian misalignment caused by shift work affects fertility and the fetus, increasing the risk of miscarriage, premature birth and low birth weight, phenomena observed in night workers. Thus, we hypothesize that light-induced melatonin suppression as a result of night work may alter intrauterine metabolic programming in pregnant women, potentially leading to metabolic disorders in their offspring. (AU)

• Processo FAPESP: 14/50457-0 - Melatonina e a regulação do metabolismo energético: estudos básicos, clínicos e epidemiológicos
• Beneficiário: José Cipolla Neto
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 16/11155-3 - Saúde, alimentação e estilo de vida de seringueiros e trabalhadores diurnos e noturnos que vivem em ambientes urbanos.
• Beneficiário: Claudia Roberta de Castro Moreno
• Modalidade de apoio: Auxílio à Pesquisa - Regular