| Full text | |
| Author(s): |
Nehme, P. A.
[1]
;
Amaral, F.
[2]
;
Lowden, A.
[3]
;
Skene, D. J.
[4]
;
Cipolla-Neto, J.
[5, 6]
;
Moreno, C. R. C.
[1, 3]
Total Authors: 6
|
| Affiliation: | [1] Univ Sao Paulo, Sch Publ Hlth, Sao Paulo - Brazil
[2] Univ Fed Sao Paulo, Dept Physiol, Sao Paulo - Brazil
[3] Univ Stockholm, Stress Res Inst, Stockholm - Sweden
[4] Univ Surrey, Fac Hlth & Med Sci, Guildford, Surrey - England
[5] Univ Sao Paulo, Inst Biomed Sci, Dept Physiol, Sao Paulo - Brazil
[6] Univ Sao Paulo, Inst Biomed Sci, Biophys Neurobiol Lab, Sao Paulo - Brazil
Total Affiliations: 6
|
| Document type: | Journal article |
| Source: | Medical Hypotheses; v. 132, NOV 2019. |
| Web of Science Citations: | 0 |
| Abstract | |
Several novel animal studies have shown that intrauterine metabolic programming can be modified in the event of reduced melatonin synthesis during pregnancy, leading to glucose intolerance and insulin resistance in the offspring. It is therefore postulated that female night workers when pregnant may expose the offspring to unwanted health threats. This may be explained by the fact that melatonin is essential for regulating energy metabolism and can influence reproductive activity. Moreover, the circadian misalignment caused by shift work affects fertility and the fetus, increasing the risk of miscarriage, premature birth and low birth weight, phenomena observed in night workers. Thus, we hypothesize that light-induced melatonin suppression as a result of night work may alter intrauterine metabolic programming in pregnant women, potentially leading to metabolic disorders in their offspring. (AU) | |
| FAPESP's process: | 14/50457-0 - Melatonin and the control of energy metabolism: basic, clinical and epidemiological research |
| Grantee: | José Cipolla Neto |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 16/11155-3 - Lifestyle, food intake, and health of rubber tappers and day and night workers living in urban environments. |
| Grantee: | Claudia Roberta de Castro Moreno |
| Support Opportunities: | Regular Research Grants |