Melatonin physiology and pathophysiology, basic and clinical studies: characterization of the primary and secundary Hypomelatoninemia Syndromes

• Grant number: 19/24327-5
• Support Opportunities: Research Projects - Thematic Grants
• Start date: February 01, 2021
• End date: January 31, 2026
• Field of knowledge: Biological Sciences - Physiology - Physiology of Organs and Systems
• Principal Investigator: José Cipolla Neto
• Grantee: José Cipolla Neto
• Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated researchers: Adriana Aparecida Siviero Miachon ; Andrea Maria Cappellano ; Angela Maria Spinola Castro ; Angelo Rafael Carpinelli ; Ariane Ferreira Machado Avelar ; Bruno Halpern ; Carolina Beltrame Del Debbio ; Clarissa Bueno ; Claudia Roberta de Castro Moreno ; Cristoforo Scavone ; DIEGO DE CASTRO DOS SANTOS ; Elaine Cristina Marqueze ; Elisa Mitiko Kawamoto Iwashe ; Fernanda Gaspar Do Amaral ; Fernanda Marques da Cunha ; Fernando Maurício Francis Abdalla ; Gisele Giannocco ; Jackson Cioni Bittencourt ; Kátia de Angelis Lobo D Avila ; Leandro Campos de Brito ; Leticia Maria Santoro Franco Azevedo Soster ; Luciana Aparecida Campos Baltatu ; Maria Lucia Cardillo Corrêa Giannella ; Maria Paz Loayza Hidalgo ; Maria Regina Lopes Sandoval ; Maria Tereza Nunes ; Maristela de Oliveira Poletini ; Nasjla Saba da Silva ; Ovidiu Constantin Baltatu ; Raphael Escorsim Szawka ; Raquel Chacon Ruiz Martinez ; Rubens Gisbert Cury ; Solange Castro Afeche ; Taiza Stumpp Teixeira
• Associated scholarship(s): 24/10246-1 - Lactation onset and urinary 6-sulphatoxymelatonin concentration in diabetic and control postpartum women, BP.IC; 23/01780-1 - DIET QUALITY AND MEALTIME OF NIGHT WORKERS IN CLIMATERIAL: AN INTERVENTION STUDY WITH EXOGENOUS MELATONIN, BP.MS; 22/15519-0 - ROLE OF MATERNAL MELATONIN IN FETAL PROGRAMMING IN ADULT ANIMAL: ANALYSIS OF HIPPOCAMPAL CHOLINERGIC MUSCARINIC RECEPTORS, BP.IC; 22/04365-2 - Intervention with exogenous melatonin: reduction of the effects of the Climacteric Syndrome in night health workers of a hospital in São Paulo, BP.DD; 21/09923-0 - The role of melatonin on the heritable variation in the endocrine pancreas of the offspring of rats in hypomelatoninemia during pregnancy: From B cell transdifferentiation to epigenetics., BP.PD

Abstract

Using a new conceptual framework of analysis of melatonin physiology and pathophysiology, the aim of this project is to study the Hypomelatoninemia Syndrome, either primary or secondary. The project is divided in three groups of research. The first group aims to study the consequences of the absence and therapeutic replacement of melatonin onseveral aspects of pregnancy physiology and fetal development and programming. In addition of studying maternal pancreatic remodelling, melatonin synthesis and maternal neurogenesis, the offspring (male and female) will be studied just after weaning, as young and during the aging process. The physiological and pathophysiological areas included in this experimental study are glucose metabolism, lipid metabolism, energy metabolism, male and female reproduction, thyroid endocrinology, cardiovascular system and blood pressure regulation, circadian rhythmicity, learning ability, neural plasticity and neural susceptibility to drug action. The second group of research aims to characterize the human Hypomelatoninemic Syndrome, either primary or secondary, in several clinical conditions. The patients (pinealectomized, Diabetes type 1, Parkinson Disease, Autism and Bipolar Disorders) will be studied on glucose, lipid and energy metabolism, cardiovascular system, blood pressure regulation and heart rate variability, in addition to sleep and circadian rhythmicity. Moreover, the correlation between environmental illumination, melatonin synthesis and individual and transgenerational health will be considered in three situations: ICU patients, physiological adaptation to acute aerobic exercise and metabolic health and neural development of children born to mothers that worked during the night when pregnant. Finaly, in a third group of research the aim is to study the balance between pineal melatonin and local produced melatonin on retinal and cerebral coroid plexus functions. (AU)

Scientific publications

(8)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

OLIVEIRA, GUSTAVO F.; MARIN, THAIS C.; BARBOSA, JULIO C. C. L.; AZEVEDO, LUAN M.; THOSAR, SAURABH S.; CIPOLLA-NETO, JOSE; FORJAZ, CLAUDIA L. M.; BRITO, LEANDRO C.. Bright light increases blood pressure and rate-pressure product after a single session of aerobic exercise in men. PHYSIOLOGICAL REPORTS, v. 12, n. 14, p. 9-pg., 2024-07-01. (19/24327-5, 22/12605-3, 18/05226-0)

COELHO, LIA ALENCAR; SILVA, LUCIANO ANDRADE; REWAY, ANA PAULA; BUONFIGLIO, DANIELLA DO CARMO; ANDRADE-SILVA, JESSICA; GOMES, PATRICIA RODRIGUES LOURENCO; CIPOLLA-NETO, JOSE. Seasonal Variation of Melatonin Concentration and mRNA Expression of Melatonin-Related Genes in Developing Ovarian Follicles of Mares Kept under Natural Photoperiods in the Southern Hemisphere. ANIMALS, v. 13, n. 6, p. 12-pg., 2023-03-01. (14/17830-9, 19/24327-5)

SARAIVA, S.; D'AUREA, C.; NEHME, P.; AMARAL, F.; CIPOLLA-NETO, J.; MARQUEZE, E.; MORENO, C.. NIGHT SHIFT WORK AND MENOPAUSE: ASSOCIATION BETWEEN CLIMACTERIC SYMPTOMS, REPORTED PSYCHIC SYMPTOMS, AND HORMONAL PROFILE OF FEMALE NIGHT SHIFT WORKERS DURING THE MENOPAUSE. Sleep Medicine, v. 115, p. 2-pg., 2024-02-01. (19/24327-5, 22/04365-2)

OLIVEIRA-ABREU, KLAUSEN; CIPOLLA-NETO, JOSE; LEAL-CARDOSO, JOSE HENRIQUE. Effects of Melatonin on Diabetic Neuropathy and Retinopathy. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 23, n. 1, p. 14-pg., 2022-01-01. (19/24327-5)

D'AUREA, C. V. R.; AMARAL, F. G.; CIPOLLA-NETO, J.; MORENO, C. RC; MARQUEZE, E. C.. CARDIOMETABOLIC PARAMETERS IN NIGHT WORKERS DURING THE MENOPAUSAL TRANSITION PERIOD AFTER MELATONIN INTERVENTION. Sleep Medicine, v. 115, p. 2-pg., 2024-02-01. (19/24327-5)

MONTEIRO, KARLA KRISLANE ALVES COSTA; DAMOUS, LUCIANA LAMARAO; SHIROMA, MARCOS EIJI; TERMINI, LARA; CIPOLLA-NETO, JOSE; SIMOES, RICARDO DOS SANTOS; DA SILVA, RINALDO FLORENCIO; TURRI, JOSE ANTONIO; BARACAT, EDMUND C.; SOARES-JUNIOR, JOSE MARIA. Melatonin increases superoxide dismutase 2 (SOD2) levels and improves rat ovarian graft function after transplantation. JOURNAL OF OVARIAN RESEARCH, v. 17, n. 1, p. 13-pg., 2024-10-16. (18/24224-9, 19/24327-5)

CAMPOS, LUCIANA APARECIDA; BALTATU, OVIDIU CONSTANTIN; SENAR, SERGIO; GHIMOUZ, RYM; ALEFISHAT, EMAN; CIPOLLA-NETO, JOSE. Multiplatform-Integrated Identification of Melatonin Targets for a Triad of Psychosocial-Sleep/Circadian-Cardiometabolic Disorders. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 24, n. 1, p. 22-pg., 2023-01-01. (19/24327-5, 17/11976-0)

VIEIRA, R. P. O.; NEHME, P. X. S. A.; MARQUEZE, E. C.; AMARAL, F. G.; CIPOLLA-NETO, J.; MORENO, C. R. C.. High social jetlag is correlated with nocturnal inhibition of melatonin production among night workers. CHRONOBIOLOGY INTERNATIONAL, v. 38, n. 8, p. 1170-1176, AUG 3 2021. (14/50457-0, 19/24327-5, 16/11155-3)