Central growth hormone action regulates metabolism during pregnancy

Autor(es)

Teixeira, Pryscila D. S. ^[1] ; Couto, Gisele C. ^[1] ; Furigo, Isadora C. ^[1] ; List, Edward O. ^{[2, 3]} ; Kopchick, John J. ^{[2, 3]} ; Donato, Jr., Jose ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Inst Biomed Sci, Dept Physiol & Biophys, Sao Paulo - Brazil

^[2] Ohio Univ, Edison Biotechnol Inst, Athens, OH 45701 - USA

^[3] Ohio Univ, Heritage Coll Osteopath Med, Athens, OH 45701 - USA

• Tipo de documento: Artigo Científico
• Fonte: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM; v. 317, n. 5, p. E925-E940, NOV 2019.
• Citações Web of Science: 1

Resumo

The maternal organism undergoes numerous metabolic adaptations to become prepared for the demands associated with the coming offspring. These metabolic adaptations involve changes induced by several hormones that act at multiple levels, ultimately influencing energy and glucose homeostasis during pregnancy and lactation. Previous studies have shown that central growth hormone (GH) action modulates glucose and energy homeostasis. However, whether central GH action regulates metabolism during pregnancy and lactation is still unknown. In the present study, we generated mice carrying ablation of GH receptor (GHR) in agouti-related protein (AgRP)-expressing neurons, in leptin receptor (LepR)-expressing cells or in the entire brain to investigate the role played by central GH action during pregnancy and lactation. AgRP-specific GHR ablation led to minor metabolic changes during pregnancy and lactation. However, while brain-specific GHR ablation reduced food intake and body adiposity during gestation, LepR GHR knockout (KO) mice exhibited increased leptin responsiveness in the ventromedial nucleus of the hypothalamus during late pregnancy, although their offspring showed reduced growth rate. Additionally, both Brain GHR KO and LepR GHR KO mice had lower glucose tolerance and glucose-stimulated insulin secretion during pregnancy, despite presenting increased insulin sensitivity, compared with control pregnant animals. Our findings revealed that during pregnancy central GH action regulates food intake, fat retention, as well as the sensitivity to insulin and leptin in a cell-specific manner. Together, the results suggest that GH acts in concert with other ``gestational hormones{''} to prepare the maternal organism for the metabolic demands of the offspring. (AU)

• Processo FAPESP: 17/02983-2 - Ação do hormônio do crescimento no sistema nervoso: relevância para as funções neurais e na doença
• Beneficiário: Jose Donato Junior
• Linha de fomento: Auxílio à Pesquisa - Temático
• Processo FAPESP: 17/04006-4 - A importância da ação do hormônio do crescimento sobre os neurônios NPY/AgRP do hipotálamo
• Beneficiário: Gisele Cristina Lopes Couto Spiri
• Linha de fomento: Bolsas no Brasil - Mestrado
• Processo FAPESP: 16/09679-4 - Estudo dos efeitos centrais do hormônio do crescimento sobre o metabolismo energético e controle glicêmico
• Beneficiário: Isadora Clivatti Furigo
• Linha de fomento: Bolsas no Brasil - Pós-Doutorado