Aerobic Exercise Training and Nontraditional Cardiovascular Risk Factors in Hemodialysis Patients: Results from a Prospective Randomized Trial

Autor(es):Mostrar menos -

Oliveira e Silva, Viviana Rugolo ^[1] ; Belik, Fernanda Stringuetta ^[1] ; Hueb, Joao Carlos ^[2] ; Goncalves, Renato de Souza ^[2] ; Teixeira Caramori, Jacqueline Costa ^[1] ; Vogt, Barbara Perez ^[1] ; Barretti, Pasqual ^[1] ; Zanati Bazan, Silmeia Garcia ^[2] ; Mengue Feniman De Stefano, Greicy Mara ^[1] ; Martin, Luis Cuadrado ^[1] ; da Silva Franco, Roberto Jorge ^[1]

Afiliação do(s) autor(es)

^[1] Sao Paulo State Univ UNESP, Botucatu Med Sch, Dept Internal Med, Div Nephrol, BR-18618687 Botucatu, SP - Brazil

^[2] Sao Paulo State Univ UNESP, Botucatu Med Sch, Dept Internal Med, Div Cardiol, Botucatu, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: CARDIORENAL MEDICINE; v. 9, n. 6, p. 391-399, NOV 2019.
• Citações Web of Science: 0

Resumo

Introduction: Chronic kidney disease (CKD) patients have a high incidence of cardiovascular diseases (CVD) which increases their morbidity and mortality. A sedentary lifestyle in CKD is directly linked to the onset of CVD. Physical activity can bring beneficial effects to CKD patients. Aims: The aim of this study was assess the impact of aerobic training on nontraditional cardiovascular risk factors in CKD patients on hemodialysis. Materials and Methods: This is a prospective, controlled, and randomized clinical trial with analysis of intention to treat. Thirty patients underwent an exercise treadmill test, an arterial stiffness evaluation, echocardiography and analysis of endothelial reactivity, and carotid ultrasound and laboratorial tests, including analysis of serum aldosterone. The intervention group (IG) (n =15) underwent aerobic exercise during hemodialysis 3 times a week for 4 months. The control group (CG) (n =15) had no intervention. All of the patients were reassessed after 4 months. Results: In the IG, there was a statistically significant improvement in flow-mediated vasodilation (FMV; p = 0.002) and a reduction in left ventricular hypertrophy (p = 0.006) and serum aldosterone (p = 0.016). There was an increase in C-reactive protein in the CG (p = 0.002). Conclusion: This aerobic training protocol was able to improve endothelial function with enhanced FMV and reduce left ventricular hypertrophy and serum aldosterone, which could have a positive impact on the reduction of nontraditional cardiovascular risk factors in CKD patients on hemodialysis. (AU)

• Processo FAPESP: 09/02060-5 - Influência da atividade física sobre a pressão arterial avaliada por monitorização residencial da pressão arterial, pressão arterial central e velocidade de onda de pulso em pacientes de hemodiálise
• Beneficiário: Roberto Jorge da Silva Franco
• Linha de fomento: Auxílio à Pesquisa - Regular