Ischemia/Reperfusion Injury Revisited: An Overview of the Latest Pharmacological Strategies

Autor(es)

Soares, Ricardo O. S. ^[1] ; Losada, Daniele M. ^[2] ; Jordani, Maria C. ^[3] ; Evora, Paulo ^{[3, 4]} ; Castro-e-Silva, Orlando ^{[3, 4]}

Afiliação do(s) autor(es)

^[1] Marilia Med Sch, BR-17519030 Marilia, SP - Brazil

^[2] Univ Estadual Campinas, Dept Anat Pathol, Fac Med Sci, BR-13083970 Campinas, SP - Brazil

^[3] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Surg & Anat, BR-14049900 Ribeirao Preto - Brazil

^[4] Univ Sao Paulo, Sao Paulo Med Sch, Dept Gastroenterol, BR-01246903 Sao Paulo, SP - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES; v. 20, n. 20 OCT 2 2019.
• Citações Web of Science: 0

Resumo

Ischemia/reperfusion injury (IRI) permeates a variety of diseases and is a ubiquitous concern in every transplantation proceeding, from whole organs to modest grafts. Given its significance, efforts to evade the damaging effects of both ischemia and reperfusion are abundant in the literature and they consist of several strategies, such as applying pre-ischemic conditioning protocols, improving protection from preservation solutions, thus providing extended cold ischemia time and so on. In this review, we describe many of the latest pharmacological approaches that have been proven effective against IRI, while also revisiting well-established concepts and presenting recent pathophysiological findings in this ever-expanding field. A plethora of promising protocols has emerged in the last few years. They have been showing exciting results regarding protection against IRI by employing drugs that engage several strategies, such as modulating cell-surviving pathways, evading oxidative damage, physically protecting cell membrane integrity, and enhancing cell energetics. (AU)

• Processo FAPESP: 13/07276-1 - CEPOF - Centro de Pesquisa em Óptica e Fotônica
• Beneficiário: Vanderlei Salvador Bagnato
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs