From yeast to humans: Understanding the biology of DNA Damage Response (DDR) kinases

Autor(es)

José Renato Rosa Cussiol ^[1] ; Bárbara Luísa Soares ^[2] ; Francisco Meirelles Bastos de Oliveira ^[3]

Afiliação do(s) autor(es)

^[1] Universidade Federal de São Paulo. Departamento de Bioquímica - Brasil

^[2] Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho - Brasil

^[3] Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho - Brasil

• Tipo de documento: Artigo Científico
• Fonte: GENETICS AND MOLECULAR BIOLOGY; v. 43, n. 1 2019-12-13.

Resumo

Abstract The DNA Damage Response (DDR) is a complex network of biological processes that protect cells from accumulating aberrant DNA structures, thereby maintaining genomic stability and, as a consequence, preventing the development of cancer and other diseases. The DDR pathway is coordinated by a signaling cascade mediated by the PI3K-like kinases (PIKK) ATM and ATR and by their downstream kinases CHK2 and CHK1, respectively. Together, these kinases regulate several aspects of the cellular program in response to genomic stress. Much of our understanding of these kinases came from studies performed in the 1990s using yeast as a model organism. The purpose of this review is to present a historical perspective on the discovery of the DDR kinases in yeast and the importance of this model for the identification and functional understanding of their mammalian orthologues. (AU)

• Processo FAPESP: 18/05417-0 - Vias de sinalização de dano no DNA: mecanismos de regulação e integração com o metabolismo celular
• Beneficiário: José Renato Rosa Cussiol
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores