The Gastrointestinal Tumor Microenvironment: An Updated Biological and Clinical Perspective

Autor(es)

Batista, Silvia ^[1] ; Gregorio, Ana C. ^[1] ; Otake, Andreia Hanada ^{[1, 2]} ; Couto, Nuno ^{[1, 3]} ; Costa-Silva, Bruno ^[1]

Afiliação do(s) autor(es)

^[1] Champalimaud Res, Champalimaud Ctr Unknown, P-1400038 Lisbon - Portugal

^[2] Univ Sao Paulo, Fac Med, Hosp Clin HCFMUSP, Ctr Translat Res Oncol LIM 24, Inst Canc Estado Sa, BR-01246000 Sao Paulo, SP - Brazil

^[3] Champalimaud Clin Ctr, Digest Unit, P-1400038 Lisbon - Portugal

• Tipo de documento: Artigo de Revisão
• Fonte: JOURNAL OF ONCOLOGY; v. 2019, NOV 22 2019.
• Citações Web of Science: 0

Resumo

Gastrointestinal cancers are still responsible for high numbers of cancer-related deaths despite advances in therapy. Tumor-associated cells play a key role in tumor biology, by supporting or halting tumor development through the production of extracellular matrix, growth factors, cytokines, and extracellular vesicles. Here, we review the roles of these tumor-associated cells in the initiation, angiogenesis, immune modulation, and resistance to therapy of gastrointestinal cancers. We also discuss novel diagnostic and therapeutic strategies directed at tumor-associated cells and their potential benefits for the survival of these patients. (AU)

• Processo FAPESP: 19/00740-0 - Exosomos do fígado com nicho pré-metastático como mediadores da metástase hepática de adenocarcinoma de pâncreas
• Beneficiário: Andréia Hanada Otake
• Modalidade de apoio: Bolsas no Exterior - Pesquisa