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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

The Gastrointestinal Tumor Microenvironment: An Updated Biological and Clinical Perspective

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Author(s):
Batista, Silvia [1] ; Gregorio, Ana C. [1] ; Otake, Andreia Hanada [1, 2] ; Couto, Nuno [1, 3] ; Costa-Silva, Bruno [1]
Total Authors: 5
Affiliation:
[1] Champalimaud Res, Champalimaud Ctr Unknown, P-1400038 Lisbon - Portugal
[2] Univ Sao Paulo, Fac Med, Hosp Clin HCFMUSP, Ctr Translat Res Oncol LIM 24, Inst Canc Estado Sa, BR-01246000 Sao Paulo, SP - Brazil
[3] Champalimaud Clin Ctr, Digest Unit, P-1400038 Lisbon - Portugal
Total Affiliations: 3
Document type: Review article
Source: JOURNAL OF ONCOLOGY; v. 2019, NOV 22 2019.
Web of Science Citations: 0
Abstract

Gastrointestinal cancers are still responsible for high numbers of cancer-related deaths despite advances in therapy. Tumor-associated cells play a key role in tumor biology, by supporting or halting tumor development through the production of extracellular matrix, growth factors, cytokines, and extracellular vesicles. Here, we review the roles of these tumor-associated cells in the initiation, angiogenesis, immune modulation, and resistance to therapy of gastrointestinal cancers. We also discuss novel diagnostic and therapeutic strategies directed at tumor-associated cells and their potential benefits for the survival of these patients. (AU)

FAPESP's process: 19/00740-0 - Exosomes released by pre-metastatic niche-containing liver as mediators of pancreas adenocarcinoma liver metastasis
Grantee:Andréia Hanada Otake
Support Opportunities: Scholarships abroad - Research