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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Central growth hormone signaling is not required for the timing of puberty

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Autor(es):
Bohlen, Tabata M. [1] ; Zampieri, Thais T. [1] ; Furigo, Isadora C. [2] ; Teixeira, Pryscila D. S. [2] ; List, Edward O. [3, 4] ; Kopchick, John J. [3, 4] ; Donato, Jr., Jose [2] ; Frazao, Renata [1]
Número total de Autores: 8
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Inst Biomed Sci, Dept Anat, Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Inst Biomed Sci, Dept Physiol & Biophys, Sao Paulo, SP - Brazil
[3] Ohio Univ, Edison Biotechnol Inst, Athens, OH 45701 - USA
[4] Ohio Univ, Heritage Coll Osteopath Med, Athens, OH 45701 - USA
Número total de Afiliações: 4
Tipo de documento: Artigo Científico
Fonte: Journal of Endocrinology; v. 243, n. 3, p. 161-173, DEC 2019.
Citações Web of Science: 2
Resumo

Growth hormone (GH) is a key factor in the regulation of body growth, as well as a variety of other cellular and metabolic processes. Neurons expressing kisspeptin and leptin receptors (LepR) have been shown to modulate the hypothalamic-pituitary-gonadal (HPG) axis and are considered GH responsive. The presence of functional GH receptors (GHR) in these neural populations suggests that GH may regulate the HPG axis via a central mechanism. However, there have been no studies evaluating whether or not GH-induced intracellular signaling in the brain plays a role in the timing of puberty or mediates the ovulatory cycle. Toward the goal of understanding the influence of GH on the central nervous system as a mediator of reproductive functions, GHR ablation was induced in kisspeptin and LepR-expressing cells or in the entire brain. The results demonstrated that GH signaling in specific neural populations can potentially modulate the hypothalamic expression of genes related to the reproductive system or indirectly contribute to the progression of puberty. GH action in kisspeptin cells or in the entire brain was not required for sexual maturation. On the other hand, GHR ablation in LepR cells delayed puberty progression, reduced serum leptin levels, decreased body weight gain and compromised the ovulatory cycle in some individuals, while the lack of GH effects in the entire brain prompted shorter estrous cycles. These findings suggest that GH can modulate brain components of the HPG axis, although central GH signaling is not required for the timing of puberty. (AU)

Processo FAPESP: 15/20198-5 - Papel da leptina na neuromodulação puberal
Beneficiário:Thais Tessari Zampieri
Linha de fomento: Bolsas no Brasil - Pós-Doutorado
Processo FAPESP: 15/14588-5 - Influência da sensibilidade à leptina na maturação sexual de camundongos
Beneficiário:Tabata Mariz Bohlen
Linha de fomento: Bolsas no Brasil - Doutorado
Processo FAPESP: 17/02983-2 - Ação do hormônio do crescimento no sistema nervoso: relevância para as funções neurais e na doença
Beneficiário:Jose Donato Junior
Linha de fomento: Auxílio à Pesquisa - Temático
Processo FAPESP: 16/09679-4 - Estudo dos efeitos centrais do hormônio do crescimento sobre o metabolismo energético e controle glicêmico
Beneficiário:Isadora Clivatti Furigo
Linha de fomento: Bolsas no Brasil - Pós-Doutorado