Busca avançada
Ano de início
Entree
(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Relationship between footshock intensity, post-training corticosterone release and contextual fear memory specificity over time

Texto completo
Autor(es):
Correa, Moises dos Santos [1] ; Vaz, Barbara dos Santos [1] ; Vieira Grisanti, Gabriel David [1] ; Queiroz de Paiva, Joselisa Peres [2] ; Tiba, Paula Ayako [1] ; Fornari, Raquel Vecchio [1]
Número total de Autores: 6
Afiliação do(s) autor(es):
[1] UFABC, CMCC, Sao Bernardo Do Campo, SP - Brazil
[2] HIAE, Inst Brain, Sao Paulo, SP - Brazil
Número total de Afiliações: 2
Tipo de documento: Artigo Científico
Fonte: PSYCHONEUROENDOCRINOLOGY; v. 110, DEC 2019.
Citações Web of Science: 0
Resumo

Overgeneralized fear has long been implicated in generalized anxiety and post-traumatic stress disorder, however, time-dependent mechanisms underlying memory retrieval are still not completely understood. Previous studies have revealed that stronger fear conditioning training protocols are associated with both increased post-training corticosterone (CORT) levels and fear responses at later retrieval tests. Here we used contextual fear conditioning (CFC) to investigate the relationship between post-training CORT levels and memory specificity in different retrieval timepoints. Wistar rats were exposed to CFC training with increasing footshock intensities (0.3, 0.6 or 1.0mA) and had their blood collected 30 min afterwards to measure post-training plasma CORT. After 2, 14 or 28 days, rats were tested for memory specificity either in the training or in the novel context. Regression analysis was used to verify linear and non-linear interactions between CORT levels and freezing. Higher footshock intensities increased post-training CORT levels and freezing times during tests in all timepoints. Moreover, stronger trainings elicited faster memory generalization, which was associated with higher CORT levels during memory consolidation. The 0.3mA training maintained memory specificity up to 28 days. Additionally, linear regressions suggest that the shift from specific to generalized memories is underway at 14 days after training. These results are consistent with the hypotheses that stronger training protocols elicit a faster generalization rate, and that this process is associated with increased post-training CORT release. (AU)

Processo FAPESP: 11/10062-8 - A relação entre sono, hormônios do eixo HPA e processos cognitivos
Beneficiário:Paula Ayako Tiba
Modalidade de apoio: Auxílio à Pesquisa - Regular
Processo FAPESP: 15/26983-6 - Efeito de diferentes intensidades de choque durante o treino de condicionamento de medo ao contexto sobre os níveis de corticosterona plasmática e a especificidade da memória contextual em ratos
Beneficiário:Moisés dos Santos Corrêa
Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
Processo FAPESP: 17/03820-0 - Dinâmica temporal da modulação da memória pela corticosterona
Beneficiário:Raquel Vecchio Fornari
Modalidade de apoio: Auxílio à Pesquisa - Regular