Sleep deprivation changes thimet oligopeptidase (THOP1) expression and activity in rat brain

Autor(es)

Visniauskas, Bruna ^[1] ; Simoes, Priscila S. R. ^[2] ; Dalio, Fernanda M. ^[3] ; Naffah-Mazzacoratti, Maria D. G. ^[2] ; Oliveira, Vitor ^[3] ; Tufik, Sergio ^[1] ; Chagas, Jair R. ^{[1, 3]}

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo, Dept Psychobiol, BR-04024002 Sao Paulo, SP - Brazil

^[2] Univ Fed Sao Paulo, Dept Neurol Neurosurg, BR-04039032 Sao Paulo, SP - Brazil

^[3] Univ Fed Sao Paulo, Dept Biophys, BR-04039032 Sao Paulo, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: HELIYON; v. 5, n. 11 NOV 2019.
• Citações Web of Science: 0

Resumo

The consequences of sleep deprivation on memory, cognition, nociception, stress, and endocrine function are related to the balance of neuropeptides, with peptidases being particularly essential. Thimet oligopeptidase (THOP1) is a metallopeptidase implicated in the metabolism of many sleep-related peptides, including angiotensin I, gonadotropin releasing hormone (GnRH), neurotensin, and opioid peptides. In the present study, we evaluated the effect of sleep deprivation and sleep recovery in male rats on THOP1 expression and specific activity in the central nervous system. In the striatum and hypothalamus, THOP1 activity decreased following sleep deprivation and a recovery period. Meanwhile, THOP1 activity and immunoexpression increased in the hippocampal dentate gyrus during the sleep recovery period. Changes in THOP1 expression after sleep deprivation and during sleep recovery can potentially alter the processing of neuropeptides. In particular, processing of opioid peptides may be related to the known increase in pain sensitivity in this model. These results suggest that THOP1 may be an important player in the effects of sleep deprivation. (AU)

• Processo FAPESP: 12/02123-0 - Interação do sistema calicreínas-cininas e fator de crescimento vascular endotelial (VEGF) em modelos animais de hipóxia intermitente
• Beneficiário: Bruna Visniauskas
• Modalidade de apoio: Bolsas no Brasil - Doutorado