From yeast to humans: Understanding the biology of DNA Damage Response (DDR) kinases

Autor(es)

Rosa Cussiol, Jose Renato ^[1] ; Soares, Barbara Luisa ^[2] ; Bastos de Oliveira, Francisco Meirelles ^[2]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo, Dept Bioquim, Sao Paulo, SP - Brazil

^[2] Univ Fed Rio de Janeiro, Inst Biofis Carlos Chagas Filho, Av Carlos Chagas Filho 373, Cidade Univ, BR-21941902 Rio De Janeiro, RJ - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: GENETICS AND MOLECULAR BIOLOGY; v. 43, n. 1, 1 2020.
• Citações Web of Science: 0

Resumo

The DNA Damage Response (DDR) is a complex network of biological processes that protect cells from accumulating aberrant DNA structures, thereby maintaining genomic stability and, as a consequence, preventing the development of cancer and other diseases. The DDR pathway is coordinated by a signaling cascade mediated by the PI3K-like kinases (PIKK) ATM and ATR and by their downstream kinases CHK2 and CHK1, respectively. Together, these kinases regulate several aspects of the cellular program in response to genomic stress. Much of our understanding of these kinases came from studies performed in the 1990s using yeast as a model organism. The purpose of this review is to present a historical perspective on the discovery of the DDR kinases in yeast and the importance of this model for the identification and functional understanding of their mammalian orthologues. (AU)

• Processo FAPESP: 18/05417-0 - Vias de sinalização de dano no DNA: mecanismos de regulação e integração com o metabolismo celular
• Beneficiário: José Renato Rosa Cussiol
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores