Persistent MOG-IgG positivity is a predictor of recurrence in MOG-IgG-associated optic neuritis, encephalitis and myelitis

Autor(es)

Oliveira, Luana Michelli ^[1] ; Apostolos-Pereira, Samira Luisa ^[1] ; Pitombeira, Milena Sales ^[1] ; Bruel Torretta, Pedro Henrique ^[1] ; Callegaro, Dagoberto ^[1] ; Sato, Douglas Kazutoshi ^{[1, 2]}

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo HC FMUSP, Fac Med, Hosp Clin, Sao Paulo, SP - Brazil

^[2] Pontificia Univ Catolica Rio Grande do Sul, Inst Cerebro Rio Grande Sul InsCer, Ave Ipiranga, 6690, Predio 63, BR-90610000 Porto Alegre, RS - Brazil

• Tipo de documento: Artigo Científico
• Fonte: MULTIPLE SCLEROSIS; v. 25, n. 14, p. 1907-1914, DEC 2019.
• Citações Web of Science: 3

Resumo

Background: MOG-IgG-associated optic neuritis, encephalitis and myelitis (MONEM) is a recently recognized group of inflammatory central nervous system (CNS) disorders distinct from multiple sclerosis and neuromyelitis optica spectrum disorders. Limited data are available regarding the predictors of relapse in this condition. Objective: We aimed to evaluate the longitudinal serostatus of patients with MOG-IgG and to correlate serostatus with long-term clinical outcomes. Methods: Of 574 consecutive patients who presented with demyelinating inflammatory CNS disorders, we included 31 patients who were MOG-IgG-positive. Patients with MOG-IgG were followed up from 2011 to 2017 at the School of Medicine, University of SAo Paulo, Brazil. Results: Relapsing disease occurred in 23 out of 31 patients (74%), while 8 (26%) exhibited a monophasic course. All monophasic patients, as well as the majority of relapsing patients, became seronegative during clinical remission. Patients exhibiting disease activity in the last 2years were more likely to remain positive, with higher medium titres than those found in patients in clinical remission. Conclusion: MOG-IgG patients usually present with a relapsing course, and the risk of relapse was associated with longitudinally persistent MOG-IgG seropositivity. In contrast, patients who experienced a single attack became spontaneously seronegative for MOG-IgG during long-term follow-up. (AU)

• Processo FAPESP: 15/23968-6 - Avaliação clínica dos casos anti MOG positivos do serviço de neurologia do HC-FMUSP
• Beneficiário: Luana Michelli Oliveira de Paula Salles
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto