A simulation study of gold nanoparticles localisation effects on radiation enhancement at the mitochondrion scale

Autor(es)

Francis, Z. ^[1] ; Montarou, G. ^[2] ; Incerti, S. ^[3] ; Bernal, M. ^[4] ; Zein, S. A. ^[5]

Afiliação do(s) autor(es)

^[1] St Joseph Univ, Fac Sci, Dept Phys, Beirut - Lebanon

^[2] Clermont Auvergne Univ, Lab Phys Clermont, CNRS IN2P3, F-63000 Clermont Ferrand - France

^[3] Univ Bordeaux 1, CENBG, CNRS IN2P3, F-33175 Gradignan - France

^[4] Univ Estadual Campinas, Inst Fis Gleb Wataghin, Campinas, SP - Brazil

^[5] Weill Cornell Med Coll, Dept Radiol, New York, NY - USA

• Tipo de documento: Artigo Científico
• Fonte: PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS; v. 67, p. 148-154, NOV 2019.
• Citações Web of Science: 0

Resumo

This paper presents a Monte-Carlo study focusing on the effects of gold nanoparticles on the energy deposition patterns produced by incident photons in the close vicinity of the mitochondrial network modeled as a tube. Spherical shaped gold nanoparticles of 30 nm diameter were placed in a micrometric (10 x 10 x 10 mu m(3)) water phantom containing a tube of 300 nm diameter and 5 mu m length. The tube represented a mitochondrial fragment and nanoparticles were distributed in the water phantom outside the tube. Photons of 120 keV were simulated using the Geant4 Livermore processes and the Geant4-DNA electron processes to account for secondary electrons collisions. The Livermore processes took into account the Auger cascade inside the gold material. A data mining algorithm was then used to analyze the energy deposition clusters inside the water phantom and the tube. A comparison was made between the results obtained for a uniform distribution of nanoparticles and a vesicle distribution model. The results including energy deposition clusters are also compared to dose enhancement ratios. (AU)

• Processo FAPESP: 11/51594-2 - Desenvolvimento de um sistema computacional para a simulação da interação da radiação ionizante com o material genético humano
• Beneficiário: Mario Antonio Bernal Rodriguez
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores
• Processo FAPESP: 18/15316-7 - Estudo da interação de partículas carregadas pesadas com o DNA usando métodos computacionais
• Beneficiário: Mario Antonio Bernal Rodriguez
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores - Fase 2
• Processo FAPESP: 15/21873-8 - Desenvolvimento e implementação de metodologias para otimização de técnicas de imagens em radiologia digital
• Beneficiário: Alessandra Tomal
• Modalidade de apoio: Auxílio à Pesquisa - Regular