| Full text | |
| Author(s): |
Total Authors: 5
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| Affiliation: | [1] St Joseph Univ, Fac Sci, Dept Phys, Beirut - Lebanon
[2] Clermont Auvergne Univ, Lab Phys Clermont, CNRS IN2P3, F-63000 Clermont Ferrand - France
[3] Univ Bordeaux 1, CENBG, CNRS IN2P3, F-33175 Gradignan - France
[4] Univ Estadual Campinas, Inst Fis Gleb Wataghin, Campinas, SP - Brazil
[5] Weill Cornell Med Coll, Dept Radiol, New York, NY - USA
Total Affiliations: 5
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| Document type: | Journal article |
| Source: | PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS; v. 67, p. 148-154, NOV 2019. |
| Web of Science Citations: | 0 |
| Abstract | |
This paper presents a Monte-Carlo study focusing on the effects of gold nanoparticles on the energy deposition patterns produced by incident photons in the close vicinity of the mitochondrial network modeled as a tube. Spherical shaped gold nanoparticles of 30 nm diameter were placed in a micrometric (10 x 10 x 10 mu m(3)) water phantom containing a tube of 300 nm diameter and 5 mu m length. The tube represented a mitochondrial fragment and nanoparticles were distributed in the water phantom outside the tube. Photons of 120 keV were simulated using the Geant4 Livermore processes and the Geant4-DNA electron processes to account for secondary electrons collisions. The Livermore processes took into account the Auger cascade inside the gold material. A data mining algorithm was then used to analyze the energy deposition clusters inside the water phantom and the tube. A comparison was made between the results obtained for a uniform distribution of nanoparticles and a vesicle distribution model. The results including energy deposition clusters are also compared to dose enhancement ratios. (AU) | |
| FAPESP's process: | 11/51594-2 - Development of a computational system for the simulation of the interaction of ionizing radiations with the human genetic material |
| Grantee: | Mario Antonio Bernal Rodriguez |
| Support Opportunities: | Research Grants - Young Investigators Grants |
| FAPESP's process: | 18/15316-7 - Study of the interaction of heavy charged particles with DNA using computational methods |
| Grantee: | Mario Antonio Bernal Rodriguez |
| Support Opportunities: | Research Grants - Young Investigators Grants - Phase 2 |
| FAPESP's process: | 15/21873-8 - Establishment and application of methodologies for optimizing imaging techniques in digital radiology |
| Grantee: | Alessandra Tomal |
| Support Opportunities: | Regular Research Grants |