Current Approaches to Drug Discovery for Chagas Disease: Methodological Advances

Autor(es)

Scarim, Caue B. ^{[1, 2, 3]} ; Chin, Chung M. ^{[1, 2]}

Afiliação do(s) autor(es)

^[1] Sao Paulo State Univ, UNESP, Sch Pharmaceut Sci, Araraquara, SP - Brazil

^[2] Lapdesf Lab Res & Dev Drugs, Araraquara, SP - Brazil

^[3] Rodovia Araraquara Jau Km 1 S-N, Campus Ville, BR-14800903 Araraquara, SP - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING; v. 22, n. 8, p. 509-520, 2019.
• Citações Web of Science: 0

Resumo

Background: In recent years, there has been an improvement in the in vitro and in vivo methodology for the screening of anti-chagasic compounds. Millions of compounds can now have their activity evaluated (in large compound libraries) by means of high throughput in vitro screening assays. Objective: Current approaches to drug discovery for Chagas disease. Method: This review article examines the contribution of these methodological advances in medicinal chemistry in the last four years. focusing on Trypanosoma cruzi infection, obtained from the PubMed, Web of Science, and Scopus databases. Results: Here, we have shown that the promise is increasing each year for more lead compounds for the development of a new drug against Chagas disease. Conclusion: There is increased optimism among those working with the objective to find new drug candidates for optimal treatments against Chagas disease. (AU)

• Processo FAPESP: 16/10847-9 - Hidroximetilnitrofural (NFOH): estudo da atividade em fase crônica da Doença de Chagas em modelo animal e síntese de derivados solúveis
• Beneficiário: Cauê Benito Scarim
• Modalidade de apoio: Bolsas no Brasil - Doutorado