Current Approaches to Drug Discovery for Chagas Disease: Methodological Advances

Author(s)

Scarim, Caue B. ^{[1, 2, 3]} ; Chin, Chung M. ^{[1, 2]}

Affiliation

^[1] Sao Paulo State Univ, UNESP, Sch Pharmaceut Sci, Araraquara, SP - Brazil

^[2] Lapdesf Lab Res & Dev Drugs, Araraquara, SP - Brazil

^[3] Rodovia Araraquara Jau Km 1 S-N, Campus Ville, BR-14800903 Araraquara, SP - Brazil

• Document type: Review article
• Source: COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING; v. 22, n. 8, p. 509-520, 2019.
• Web of Science Citations: 0

Abstract

Background: In recent years, there has been an improvement in the in vitro and in vivo methodology for the screening of anti-chagasic compounds. Millions of compounds can now have their activity evaluated (in large compound libraries) by means of high throughput in vitro screening assays. Objective: Current approaches to drug discovery for Chagas disease. Method: This review article examines the contribution of these methodological advances in medicinal chemistry in the last four years. focusing on Trypanosoma cruzi infection, obtained from the PubMed, Web of Science, and Scopus databases. Results: Here, we have shown that the promise is increasing each year for more lead compounds for the development of a new drug against Chagas disease. Conclusion: There is increased optimism among those working with the objective to find new drug candidates for optimal treatments against Chagas disease. (AU)

• FAPESP's process: 16/10847-9 - Hydroxymethylnitrofurazone (NFOH): activity study in chronic phase of Chagas' Disease in an animal model and synthesis of soluble derivatives
• Grantee: Cauê Benito Scarim
• Support Opportunities: Scholarships in Brazil - Doctorate