Age at start of using tobacco on the risk of head and neck cancer: Pooled analysis in the International Head and Neck Cancer Epidemiology Consortium (INHANCE)

Autor(es):Mostrar menos -

Chang, Chun-Pin ^[1] ; Chang, Shen-Chih ^{[2, 3]} ; Chuang, Shu-Chun ^[4] ; Berthiller, Julien ^{[2, 5]} ; Ferro, Gilles ^[2] ; Matsuo, Keitaro ^{[6, 7]} ; Wunsch-Filho, Victor ^[8] ; Toporcov, Tatiana N. ^[8] ; de Carvalho, Marcos Brasilino ^[9] ; La Vecchia, Carlo ^[10] ; Olshan, Andrew F. ^[11] ; Zevallos, Jose P. ^[12] ; Serraino, Diego ^[13] ; Muscat, Joshua ^[14] ; Sturgis, Erich M. ^[15] ; Li, Guojun ^[15] ; Morgensn, Hal ter ^{[16, 17, 18]} ; Levi, Fabio ^[19] ; Dal Maso, Luigino ^[13] ; Smith, Elaine ^[20] ; Kelsey, Karl ^[21] ; McClean, Michael ^[21] ; Vaughan, Thomas L. ^[22] ; Lazarus, Philip ^[23] ; Ramroth, Heribert ^[24] ; Chen, Chu ^[22] ; Schwartz, Stephen M. ^[22] ; Winn, Deborah M. ^[25] ; Bosetti, Cristina ^[26] ; Edefonti, Valeria ^[10] ; Garavello, Werner ^[27] ; Negri, Eva ^[28] ; Hayes, Richard B. ^[29] ; Purdue, Mark P. ^[30] ; Boccia, Stefania ^{[31, 32]} ; Cadoni, Gabriella ^{[33, 34]} ; Shangina, Oxana ^[35] ; Koifman, Rosalina ^[36] ; Curado, Maria Paula ^[37] ; Vilensky, Marta ^[38] ; Swiatkowska, Beata ^[39] ; Herrero, Rolando ^[2] ; Franceschi, Silvia ^[40] ; Benhamou, Simone ^[41] ; Fernandez, Leticia ^[42] ; Menezes, Ana M. B. ^[43] ; Daudt, Alexander W. ^[44] ; Mates, Dana ^[45] ; Schantz, Stimson ^[46] ; Yu, Guo-Pei ^[47] ; Lissowska, Jolanta ^{[48, 49]} ; Brenner, Hermann ^{[50, 51, 52, 53]} ; Fabianova, Eleonora ^[30] ; Rudnai, Peter ^[54] ; Brennan, Paul ^[2] ; Boffetta, Paolo ^[55] ; Zhang, Zuo-Feng ^[3] ; Hashibe, Mia ^[1] ; Lee, Yuan-Chin Amy ^[1]

Afiliação do(s) autor(es):Mostrar menos -

^[1] Univ Utah, Sch Med, Huntsman Canc Inst, Dept Family & Prevent Med, Div Publ Hlth, 375 Chipeta Way, Suite A, Salt Lake City, UT 84108 - USA

^[2] Int Agcy Res Canc, Lyon - France

^[3] UCLA, Fielding Sch Publ Hlth, Dept Epidemiol, Los Angeles, CA - USA

^[4] Natl Hlth Res Inst, Inst Populat Hlth Sci, Zhunan Township, Miaoli County - Taiwan

^[5] Hosp Civils Lyon, Pole Informat Med Evaluat Rech, Lyon - France

^[6] Aichi Canc Ctr Res Inst, Div Canc Epidemiol & Prevent, Nagoya, Aichi - Japan

^[7] Nagoya Univ, Grad Sch Med, Dept Canc Epidemiol, Nagoya, Aichi - Japan

^[8] Univ Sao Paulo, Sch Publ Hlth, Dept Epidemiol, Sao Paulo, SP - Brazil

^[9] Heliopolis Hosp, Dept Head & Neck, Sao Paulo, SP - Brazil

^[10] Univ Milan, Dept Clin Sci & Community Hlth, Milan - Italy

^[11] Gillings Sch Global Publ Hlth, Dept Epidemiol, Chapel Hill, NC - USA

^[12] Washington Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, Div Head & Neck Surg Oncol, St Louis, MO 63110 - USA

^[13] Ctr Riferimento Oncol Aviano CRO IRCCS, Canc Epidemiol Unit, Aviano - Italy

^[14] Penn State Coll Med, Hershey, PA - USA

^[15] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 - USA

^[16] Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Med Sch, Ann Arbor, MI 48109 - USA

^[17] Univ Michigan, Sch Publ Hlth, Med Sch, Dept Environm Hlth Sci, Ann Arbor, MI 48109 - USA

^[18] Univ Michigan, Med Sch, Dept Urol, Ann Arbor, MI 48109 - USA

^[19] Lausanne Univ Hosp CHUV, Inst Social & Prevent Med IUMSP, Lausanne - Switzerland

^[20] Univ Iowa, Coll Publ Hlth, Iowa City, IA - USA

^[21] Brown Univ, Providence, RI 02912 - USA

^[22] Fred Hutchinson Canc Res Ctr, 1124 Columbia St, Seattle, WA 98104 - USA

^[23] Washington State Univ, Coll Pharm, Spokane, WA - USA

^[24] Heidelberg Univ, Heidelberg - Germany

^[25] NCI, Div Canc Epidemiol & Genet, Rockville, MD - USA

^[26] Ist Ric Farmacol Mario Negri IRCCS, Dept Oncol, Milan - Italy

^[27] Univ Milano Bicocca, Sch Med & Surg, Dept Otorhinolaryngol, Milan - Italy

^[28] Univ Milan, Dept Biomed & Clin Sci, Milan - Italy

^[29] NYU, Sch Med, Div Epidemiol, New York, NY - USA

^[30] Reg Author Publ Hlth Banska Bystrica, Banska Bystrica - Slovakia

^[31] Univ Cattolica Sacro Cuore, Inst Publ Hlth, Sect Hyg, Rome - Italy

^[32] Fdn Policlin Univ A Gemelli IRCCS, Rome - Italy

^[33] Univ Cattolica Sacro Cuore, Inst Clin Otorhinolaryngol, Dept Head & Neck Surg, Rome - Italy

^[34] Fdn Policlin Univ A Gemelli IRCCS, Ist Clin Otorinolaringoiatr, Rome - Italy

^[35] Canc Res Ctr, Moscow - Russia

^[36] Fundacao Oswaldo Cruz, Escola Nacl Suade Publ, Rio De Janeiro - Brazil

^[37] ACCAMARGO Canc Ctr, Sao Paulo, SP - Brazil

^[38] Univ Buenos Aires, Inst Oncol Angel H Roffo, Buenos Aires, DF - Argentina

^[39] Nofer Inst Occupat Med, Lodz - Poland

^[40] Ctr Riferimento Oncol Aviano CRO IRCCS, Sci Directorate, Aviano - Italy

^[41] INSERM, U1018, Natl Inst Hlth & Med Res, Villejuif - France

^[42] Inst Oncol & Radiobiol, Havana - Cuba

^[43] Univ Fed Pelotas, Pelotas, RS - Brazil

^[44] Hosp Clin Porto Alegre, Porto Alegre, RS - Brazil

^[45] Natl Inst Publ Hlth, Bucharest - Romania

^[46] New York Eye & Ear Infirm, New York, NY - USA

^[47] New York Med Coll, Sch Med, Dept Otolaryngol, Valhalla, NY 10595 - USA

^[48] Inst Oncol, Dept Canc Epidemiol & Prevent, Warsaw - Poland

^[49] M Slcasodowslca Curie Mem Canc Ctr, Warsaw - Poland

^[50] German Canc Res Ctr, Div Clin Epidemiol & Aging Res, Heidelberg - Germany

^[51] German Canc Res Ctr, German Canc Consortium DKTK, Heidelberg - Germany

^[52] German Canc Res Ctr, Div Prevent Oncol, Heidelberg - Germany

^[53] Natl Ctr Tumor Dis NCT, Heidelberg - Germany

^[54] Natl Inst Environm Hlth, Budapest - Hungary

^[55] Icahn Sch Med Mt Sinai, Tisch Canc Inst, New York, NY 10029 - USA

• Tipo de documento: Artigo Científico
• Fonte: CANCER EPIDEMIOLOGY; v. 63, DEC 2019.
• Citações Web of Science: 1

Resumo

Background: Tobacco use is a well-established risk factor for head and neck cancer (HNC). However, less is known about the potential impact of exposure to tobacco at an early age on HNC risk. Methods: We analyzed individual-level data on ever tobacco smokers from 27 case-control studies (17,146 HNC cases and 17,449 controls) in the International Head and Neck Cancer Epidemiology (INHANCE) consortium. Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using random-effects logistic regression models. Results: Without adjusting for tobacco packyears, we observed that younger age at starting tobacco use was associated with an increased HNC risk for ever smokers (OR (< 10 years vs. >= 30 years): 1.64, 95% CI: 1.35, 1.97). However, the observed association between age at starting tobacco use and HNC risk became null after adjusting for tobacco packyears (OR (< 10 years vs. >= 30 years): 0.97, 95% CI: 0.80, 1.19). In the stratified analyses on HNC subsites by tobacco packyears or years since quitting, no difference in the association between age at start and HNC risk was observed. Conclusions: Results from this pooled analysis suggest that increased HNC risks observed with earlier age at starting tobacco smoking are largely due to longer duration and higher cumulative tobacco exposures. (AU)

• Processo FAPESP: 10/51168-0 - Fatores ambientais, clínicos, histopatológicos e moleculares associados ao desenvolvimento e ao prognóstico de carcinomas epidermoides de cabeça e pescoço
• Beneficiário: Eloiza Helena Tajara da Silva
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 01/01768-2 - Estudo internacional de fatores ambientais, vírus e câncer de cavidade oral e de laringe
• Beneficiário: José Eluf Neto
• Modalidade de apoio: Auxílio à Pesquisa - Regular