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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Age at start of using tobacco on the risk of head and neck cancer: Pooled analysis in the International Head and Neck Cancer Epidemiology Consortium (INHANCE)

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Author(s):
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Chang, Chun-Pin [1] ; Chang, Shen-Chih [2, 3] ; Chuang, Shu-Chun [4] ; Berthiller, Julien [2, 5] ; Ferro, Gilles [2] ; Matsuo, Keitaro [6, 7] ; Wunsch-Filho, Victor [8] ; Toporcov, Tatiana N. [8] ; de Carvalho, Marcos Brasilino [9] ; La Vecchia, Carlo [10] ; Olshan, Andrew F. [11] ; Zevallos, Jose P. [12] ; Serraino, Diego [13] ; Muscat, Joshua [14] ; Sturgis, Erich M. [15] ; Li, Guojun [15] ; Morgensn, Hal ter [16, 17, 18] ; Levi, Fabio [19] ; Dal Maso, Luigino [13] ; Smith, Elaine [20] ; Kelsey, Karl [21] ; McClean, Michael [21] ; Vaughan, Thomas L. [22] ; Lazarus, Philip [23] ; Ramroth, Heribert [24] ; Chen, Chu [22] ; Schwartz, Stephen M. [22] ; Winn, Deborah M. [25] ; Bosetti, Cristina [26] ; Edefonti, Valeria [10] ; Garavello, Werner [27] ; Negri, Eva [28] ; Hayes, Richard B. [29] ; Purdue, Mark P. [30] ; Boccia, Stefania [31, 32] ; Cadoni, Gabriella [33, 34] ; Shangina, Oxana [35] ; Koifman, Rosalina [36] ; Curado, Maria Paula [37] ; Vilensky, Marta [38] ; Swiatkowska, Beata [39] ; Herrero, Rolando [2] ; Franceschi, Silvia [40] ; Benhamou, Simone [41] ; Fernandez, Leticia [42] ; Menezes, Ana M. B. [43] ; Daudt, Alexander W. [44] ; Mates, Dana [45] ; Schantz, Stimson [46] ; Yu, Guo-Pei [47] ; Lissowska, Jolanta [48, 49] ; Brenner, Hermann [50, 51, 52, 53] ; Fabianova, Eleonora [30] ; Rudnai, Peter [54] ; Brennan, Paul [2] ; Boffetta, Paolo [55] ; Zhang, Zuo-Feng [3] ; Hashibe, Mia [1] ; Lee, Yuan-Chin Amy [1]
Total Authors: 59
Affiliation:
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[1] Univ Utah, Sch Med, Huntsman Canc Inst, Dept Family & Prevent Med, Div Publ Hlth, 375 Chipeta Way, Suite A, Salt Lake City, UT 84108 - USA
[2] Int Agcy Res Canc, Lyon - France
[3] UCLA, Fielding Sch Publ Hlth, Dept Epidemiol, Los Angeles, CA - USA
[4] Natl Hlth Res Inst, Inst Populat Hlth Sci, Zhunan Township, Miaoli County - Taiwan
[5] Hosp Civils Lyon, Pole Informat Med Evaluat Rech, Lyon - France
[6] Aichi Canc Ctr Res Inst, Div Canc Epidemiol & Prevent, Nagoya, Aichi - Japan
[7] Nagoya Univ, Grad Sch Med, Dept Canc Epidemiol, Nagoya, Aichi - Japan
[8] Univ Sao Paulo, Sch Publ Hlth, Dept Epidemiol, Sao Paulo, SP - Brazil
[9] Heliopolis Hosp, Dept Head & Neck, Sao Paulo, SP - Brazil
[10] Univ Milan, Dept Clin Sci & Community Hlth, Milan - Italy
[11] Gillings Sch Global Publ Hlth, Dept Epidemiol, Chapel Hill, NC - USA
[12] Washington Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, Div Head & Neck Surg Oncol, St Louis, MO 63110 - USA
[13] Ctr Riferimento Oncol Aviano CRO IRCCS, Canc Epidemiol Unit, Aviano - Italy
[14] Penn State Coll Med, Hershey, PA - USA
[15] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 - USA
[16] Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Med Sch, Ann Arbor, MI 48109 - USA
[17] Univ Michigan, Sch Publ Hlth, Med Sch, Dept Environm Hlth Sci, Ann Arbor, MI 48109 - USA
[18] Univ Michigan, Med Sch, Dept Urol, Ann Arbor, MI 48109 - USA
[19] Lausanne Univ Hosp CHUV, Inst Social & Prevent Med IUMSP, Lausanne - Switzerland
[20] Univ Iowa, Coll Publ Hlth, Iowa City, IA - USA
[21] Brown Univ, Providence, RI 02912 - USA
[22] Fred Hutchinson Canc Res Ctr, 1124 Columbia St, Seattle, WA 98104 - USA
[23] Washington State Univ, Coll Pharm, Spokane, WA - USA
[24] Heidelberg Univ, Heidelberg - Germany
[25] NCI, Div Canc Epidemiol & Genet, Rockville, MD - USA
[26] Ist Ric Farmacol Mario Negri IRCCS, Dept Oncol, Milan - Italy
[27] Univ Milano Bicocca, Sch Med & Surg, Dept Otorhinolaryngol, Milan - Italy
[28] Univ Milan, Dept Biomed & Clin Sci, Milan - Italy
[29] NYU, Sch Med, Div Epidemiol, New York, NY - USA
[30] Reg Author Publ Hlth Banska Bystrica, Banska Bystrica - Slovakia
[31] Univ Cattolica Sacro Cuore, Inst Publ Hlth, Sect Hyg, Rome - Italy
[32] Fdn Policlin Univ A Gemelli IRCCS, Rome - Italy
[33] Univ Cattolica Sacro Cuore, Inst Clin Otorhinolaryngol, Dept Head & Neck Surg, Rome - Italy
[34] Fdn Policlin Univ A Gemelli IRCCS, Ist Clin Otorinolaringoiatr, Rome - Italy
[35] Canc Res Ctr, Moscow - Russia
[36] Fundacao Oswaldo Cruz, Escola Nacl Suade Publ, Rio De Janeiro - Brazil
[37] ACCAMARGO Canc Ctr, Sao Paulo, SP - Brazil
[38] Univ Buenos Aires, Inst Oncol Angel H Roffo, Buenos Aires, DF - Argentina
[39] Nofer Inst Occupat Med, Lodz - Poland
[40] Ctr Riferimento Oncol Aviano CRO IRCCS, Sci Directorate, Aviano - Italy
[41] INSERM, U1018, Natl Inst Hlth & Med Res, Villejuif - France
[42] Inst Oncol & Radiobiol, Havana - Cuba
[43] Univ Fed Pelotas, Pelotas, RS - Brazil
[44] Hosp Clin Porto Alegre, Porto Alegre, RS - Brazil
[45] Natl Inst Publ Hlth, Bucharest - Romania
[46] New York Eye & Ear Infirm, New York, NY - USA
[47] New York Med Coll, Sch Med, Dept Otolaryngol, Valhalla, NY 10595 - USA
[48] Inst Oncol, Dept Canc Epidemiol & Prevent, Warsaw - Poland
[49] M Slcasodowslca Curie Mem Canc Ctr, Warsaw - Poland
[50] German Canc Res Ctr, Div Clin Epidemiol & Aging Res, Heidelberg - Germany
[51] German Canc Res Ctr, German Canc Consortium DKTK, Heidelberg - Germany
[52] German Canc Res Ctr, Div Prevent Oncol, Heidelberg - Germany
[53] Natl Ctr Tumor Dis NCT, Heidelberg - Germany
[54] Natl Inst Environm Hlth, Budapest - Hungary
[55] Icahn Sch Med Mt Sinai, Tisch Canc Inst, New York, NY 10029 - USA
Total Affiliations: 55
Document type: Journal article
Source: CANCER EPIDEMIOLOGY; v. 63, DEC 2019.
Web of Science Citations: 1
Abstract

Background: Tobacco use is a well-established risk factor for head and neck cancer (HNC). However, less is known about the potential impact of exposure to tobacco at an early age on HNC risk. Methods: We analyzed individual-level data on ever tobacco smokers from 27 case-control studies (17,146 HNC cases and 17,449 controls) in the International Head and Neck Cancer Epidemiology (INHANCE) consortium. Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using random-effects logistic regression models. Results: Without adjusting for tobacco packyears, we observed that younger age at starting tobacco use was associated with an increased HNC risk for ever smokers (OR (< 10 years vs. >= 30 years): 1.64, 95% CI: 1.35, 1.97). However, the observed association between age at starting tobacco use and HNC risk became null after adjusting for tobacco packyears (OR (< 10 years vs. >= 30 years): 0.97, 95% CI: 0.80, 1.19). In the stratified analyses on HNC subsites by tobacco packyears or years since quitting, no difference in the association between age at start and HNC risk was observed. Conclusions: Results from this pooled analysis suggest that increased HNC risks observed with earlier age at starting tobacco smoking are largely due to longer duration and higher cumulative tobacco exposures. (AU)

FAPESP's process: 10/51168-0 - Environmental, clinical, histopathological and molecular factors associated with development and prognosis of head and neck squamous cell carcinomas
Grantee:Eloiza Helena Tajara da Silva
Support type: Research Projects - Thematic Grants