Waterproof paper as a new substrate to construct a disposable sensor for the, electrochemical determination of paracetamol and melatonin

Autor(es)

Camargo, Jessica R. ^[1] ; Andreotti, Isabella A. A. ^{[1, 2]} ; Kalinke, Cristiane ^[3] ; Henrique, Julia M. ^[1] ; Bonacin, Juliano A. ^[3] ; Janegitz, Bruno C. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Carlos, Dept Ciencias Nat Matemat & Educ, BR-13600970 Araras, SP - Brazil

^[2] Univ Fed Sao Carlos, Ctr Ciencias Exatas & Tecnol, BR-13565905 Sao Carlos, SP - Brazil

^[3] Univ Estadual Campinas, Inst Quim, BR-13083970 Campinas, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Talanta; v. 208, FEB 1 2020.
• Citações Web of Science: 0

Resumo

Disposable electrochemical sensors using sustainable and cheap materials are an exciting alternative to produce new kinds of sensing platforms. Waterproof paper (WP) is a biodegradable and biocompatible material that allows dropped of the sample on its surface without absorption by fibers. Also, WP can be used for miniaturized sensors construction. In this work, a conductive ink was produced with nail polish and graphite powder, using the WP as the sensor substrate for paracetamol (PAR) and melatonin (MEL) voltammetric determination. PAR is a pharmaceutical commonly used in high doses for the relief of pain and fever, and MEL is a hormone related to several diseases besides a direct relation to sleep quality. Using differential pulse voltammetry for PAR determination, the WP sensor showed a linear response in the concentration ranging from 0.50 mu mol L-1 to 100 mu mol L-1 with a limit of detection (LOD) of 53.6 nmol L-1. Square wave voltammetry was applied for MEL determination, and the proposed electrode presented linear response ranging from 0.80 mu mol L-1 to 100 mu mol L-1 and LOD of 32.5 nmol L-1. The sensor showed excellent repeatability and reproducibility for consecutive measurements. Then, the disposable WP sensor was successfully applied in the determination of PAR and MEL in pharmaceutical and biological samples, with recovery values, above 91.1%. The described architecture allowed the manufacture of a disposable, simple, and low-cost electroanalytical device that can be used for electrochemical sensing. (AU)

• Processo FAPESP: 17/21898-6 - Novos dispositivos condutores para aplicação em sensores e biossensores eletroquímicos
• Beneficiário: Bruno Campos Janegitz
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 18/02162-1 - Sensores descartáveis utilizando papel impermeável e tinta condutora de grafite para detecção de analitos de interesse farmacêutico
• Beneficiário: Jéssica Rocha Camargo
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 17/21097-3 - Interações abelha-agricultura: perspectivas para a utilização sustentável
• Beneficiário: Osmar Malaspina
• Modalidade de apoio: Auxílio à Pesquisa - Programa BIOTA - Temático
• Processo FAPESP: 19/00473-2 - Desenvolvimento de biossensores eletroquímicos impressos em 3 dimensões (3D) com polímero PLA e grafeno para a determinação de biomoléculas e diagnóstico de doenças
• Beneficiário: Cristiane Kalinke
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 13/22127-2 - Desenvolvimento de novos materiais estratégicos para dispositivos analíticos integrados
• Beneficiário: Lauro Tatsuo Kubota
• Modalidade de apoio: Auxílio à Pesquisa - Temático