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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Waterproof paper as a new substrate to construct a disposable sensor for the, electrochemical determination of paracetamol and melatonin

Full text
Author(s):
Camargo, Jessica R. [1] ; Andreotti, Isabella A. A. [1, 2] ; Kalinke, Cristiane [3] ; Henrique, Julia M. [1] ; Bonacin, Juliano A. [3] ; Janegitz, Bruno C. [1]
Total Authors: 6
Affiliation:
[1] Univ Fed Sao Carlos, Dept Ciencias Nat Matemat & Educ, BR-13600970 Araras, SP - Brazil
[2] Univ Fed Sao Carlos, Ctr Ciencias Exatas & Tecnol, BR-13565905 Sao Carlos, SP - Brazil
[3] Univ Estadual Campinas, Inst Quim, BR-13083970 Campinas, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Talanta; v. 208, FEB 1 2020.
Web of Science Citations: 0
Abstract

Disposable electrochemical sensors using sustainable and cheap materials are an exciting alternative to produce new kinds of sensing platforms. Waterproof paper (WP) is a biodegradable and biocompatible material that allows dropped of the sample on its surface without absorption by fibers. Also, WP can be used for miniaturized sensors construction. In this work, a conductive ink was produced with nail polish and graphite powder, using the WP as the sensor substrate for paracetamol (PAR) and melatonin (MEL) voltammetric determination. PAR is a pharmaceutical commonly used in high doses for the relief of pain and fever, and MEL is a hormone related to several diseases besides a direct relation to sleep quality. Using differential pulse voltammetry for PAR determination, the WP sensor showed a linear response in the concentration ranging from 0.50 mu mol L-1 to 100 mu mol L-1 with a limit of detection (LOD) of 53.6 nmol L-1. Square wave voltammetry was applied for MEL determination, and the proposed electrode presented linear response ranging from 0.80 mu mol L-1 to 100 mu mol L-1 and LOD of 32.5 nmol L-1. The sensor showed excellent repeatability and reproducibility for consecutive measurements. Then, the disposable WP sensor was successfully applied in the determination of PAR and MEL in pharmaceutical and biological samples, with recovery values, above 91.1%. The described architecture allowed the manufacture of a disposable, simple, and low-cost electroanalytical device that can be used for electrochemical sensing. (AU)

FAPESP's process: 17/21898-6 - New conductive devices for application in electrochemical sensing and biosensing
Grantee:Bruno Campos Janegitz
Support type: Regular Research Grants
FAPESP's process: 18/02162-1 - Disposable sensors using waterproof paper and graphite conductive ink for the detection of pharmaceutical interest analyses
Grantee:Jéssica Rocha Camargo
Support type: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 17/21097-3 - Bee-agriculture interactions: perspectives to sustainable use
Grantee:Osmar Malaspina
Support type: Research Projects - Thematic Grants
FAPESP's process: 19/00473-2 - Development of 3-dimensional (3D) printed electrochemical biosensors with PLA polymer and graphene for the determination of biomolecules and diagnosis of diseases
Grantee:Cristiane Kalinke
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 13/22127-2 - Development of novel materials strategic for integrated analytical devices
Grantee:Lauro Tatsuo Kubota
Support type: Research Projects - Thematic Grants