| Texto completo | |
| Autor(es): |
Dutra, Leticia Verissimo
[1]
;
Affonso-Kaufman, Fernando Alves
[2]
;
Cafeo, Fernanda Ramires
[2]
;
Kassai, Milene Saori
[3]
;
Barbosa, Caio Parente
[4]
;
Santos Figueiredo, Francisco Winter
[1]
;
Suano-Souza, Fabiola Isabel
[3]
;
Bianco, Bianca
[2, 4]
Número total de Autores: 8
|
| Afiliação do(s) autor(es): | [1] Fac Med ABC, Postgrad Program Hlth Sci, Santo Andre, SP - Brazil
[2] Fac Med ABC, Santo Andre, SP - Brazil
[3] Fac Med ABC, Dept Pediat, Discipline Pediat, Santo Andre, SP - Brazil
[4] Fac Med ABC, Dept Collect Hlth, Discipline Sexual & Reprod Hlth & Populat Genet, Santo Andre, SP - Brazil
Número total de Afiliações: 4
|
| Tipo de documento: | Artigo Científico |
| Fonte: | BMC PREGNANCY AND CHILDBIRTH; v. 20, n. 1 DEC 31 2019. |
| Citações Web of Science: | 0 |
| Resumo | |
Background Premature birth is the main cause of mortality in children under 1 year, and vitamin D deficiency during gestation is associated with prematurity. The effects of vitamin D are mediated by its receptor, which is encoded by the VDR gene. VDR variants-such as single nucleotide variation (SNV)-are associated with increased risk of prematurity, but there are conflicting results. We evaluated serum vitamin D concentrations and the frequency of TaqI/A > G, BsmI/C > T, ApaI/C > A, and FokI/A > T VDR variants in mothers and preterm (PTN) and full-term (FTN) newborns. Methods We conducted a case-control study comprising 40 pairs of mothers and their PTNs (gestational age < 32 weeks and/or weight < 1500 g), and 92 pairs of mothers and FTNs as controls. Genotyping was performed by real-time PCR, and plasma vitamin D concentrations were measured by electrochemiluminescence. Results Vitamin D levels were significantly lower in PTN mothers. Genotypes TaqI/GG and BsmI/TT, and haplotypes AAG (TaqI/A-ApaI/A-FokI/G) and GCA (TaqI/G-ApaI/C-FokI/A) were significantly more frequent in PTN mothers, and genotypes TaqI/AG, ApaI/AA, and FokI/AG resulted in significantly lower vitamin D levels. Genotypes BsmI/TT and ApaI/AA were associated with vitamin D deficiency and 2.36 and 7.99 times greater likelihood of PTB, respectively. Vitamin D levels were also lower in PTNs, although it was not statistically significant. Genotypes BsmI/TT, ApaI/AA, and FokI/GG, and haplotype GAG (TaqI/G-ApaI/A-FokI/G) were significantly more frequent in PTNs. Those with FokI/GG genotypes had significantly lower vitamin D levels. Conclusions VDR variants contribute to variations in vitamin D concentrations and the increased risk of prematurity. (AU) | |
| Processo FAPESP: | 15/15399-1 - Evolução das concentrações de vitamina D em recém-nascidos prematuros hospitalizados |
| Beneficiário: | Fabíola Isabel Suano de Souza |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |