Clathriamide, an hexapeptide isolated from the marine sponge Clathria (Clathria) nicoleae

Autor(es):Mostrar menos -

Freire, Vitor F. ^[1] ; Slivinski, Juliano ^[1] ; Quintana-Bulla, Jairo I. ^[1] ; Moraes, Fernando C. ^[2] ; Paradas, Wladimir C. ^[2] ; Salgado, Leonardo T. ^[2] ; Pereira, Renato C. ^{[2, 3]} ; Moura, Rodrigo L. ^{[4, 5]} ; Amado-Filho, Gilberto M. ^[2] ; Ferreira, Antonio G. ^[6] ; Berlinck, Roberto G. S. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Inst Quim Sao Carlos, Sao Carlos, SP - Brazil

^[2] Inst Pesquisas Jardim Bot Rio de Janeiro, Rio De Janeiro, RJ - Brazil

^[3] Univ Fed Fluminense, Dept Biol Marinha, Niteroi, RJ - Brazil

^[4] Univ Fed Rio de Janeiro, Inst Biol, Rio De Janeiro, RJ - Brazil

^[5] Univ Fed Rio de Janeiro, Lab Sistemas Avancados Gestao, Inst Alberto Luiz Coimbra Posgrad & Pesquisa Engn, Rio De Janeiro, RJ - Brazil

^[6] Univ Fed Sao Carlos, Dept Quim, Sao Carlos, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY; v. 29, n. 6, p. 715-719, NOV-DEC 2019.
• Citações Web of Science: 0

Resumo

ABSTRACT Chemical investigation of the aqueous fraction of the ethanol extract from the Brazilian endemic marine sponge Clathria (Clathria) nicoleae Vieira de Barros, Santos & Pinheiro, 2013, Microcionidae, sampled from a 55 m deep rhodolith bed at the Amazon River mouth, led to the isolation of a new hexapeptide, clathriamide (1). HP-20 resin was used to capture compound 1 from the aqueous fraction, which was purified by additional chromatographic steps. The absolute configuration of the amino acids of 1 was determined by advanced Marfey's analysis using 5-fluoro-2,4-dinitrophenyl-Nα-L-tryptophanamide. The amino acid derivatives analyzed by ultra-performance liquid chromatography coupled to a mass spectrometry using a C8 column enabled a good chromatographic resolution of L-Ile and L-allo-Ile, previously unfeasible using C18 column. (AU)

• Processo FAPESP: 16/16033-3 - Alcaloides Bromopirrólicos do Microbioma Cultivável da Esponja Marinha Tedania brasiliensis.
• Beneficiário: Jairo Iván Quintana Bulla
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 13/50228-8 - Componentes da biodiversidade, e seus caracteres metabólicos, de ilhas do Brasil: uma abordagem integrada
• Beneficiário: Roberto Gomes de Souza Berlinck
• Modalidade de apoio: Auxílio à Pesquisa - Programa BIOTA - Temático