| Full text | |
| Author(s): Show less - |
Freire, Vitor F.
[1]
;
Slivinski, Juliano
[1]
;
Quintana-Bulla, Jairo I.
[1]
;
Moraes, Fernando C.
[2]
;
Paradas, Wladimir C.
[2]
;
Salgado, Leonardo T.
[2]
;
Pereira, Renato C.
[2, 3]
;
Moura, Rodrigo L.
[4, 5]
;
Amado-Filho, Gilberto M.
[2]
;
Ferreira, Antonio G.
[6]
;
Berlinck, Roberto G. S.
[1]
Total Authors: 11
|
| Affiliation: | [1] Univ Sao Paulo, Inst Quim Sao Carlos, Sao Carlos, SP - Brazil
[2] Inst Pesquisas Jardim Bot Rio de Janeiro, Rio De Janeiro, RJ - Brazil
[3] Univ Fed Fluminense, Dept Biol Marinha, Niteroi, RJ - Brazil
[4] Univ Fed Rio de Janeiro, Inst Biol, Rio De Janeiro, RJ - Brazil
[5] Univ Fed Rio de Janeiro, Lab Sistemas Avancados Gestao, Inst Alberto Luiz Coimbra Posgrad & Pesquisa Engn, Rio De Janeiro, RJ - Brazil
[6] Univ Fed Sao Carlos, Dept Quim, Sao Carlos, SP - Brazil
Total Affiliations: 6
|
| Document type: | Journal article |
| Source: | REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY; v. 29, n. 6, p. 715-719, NOV-DEC 2019. |
| Web of Science Citations: | 0 |
| Abstract | |
ABSTRACT Chemical investigation of the aqueous fraction of the ethanol extract from the Brazilian endemic marine sponge Clathria (Clathria) nicoleae Vieira de Barros, Santos & Pinheiro, 2013, Microcionidae, sampled from a 55 m deep rhodolith bed at the Amazon River mouth, led to the isolation of a new hexapeptide, clathriamide (1). HP-20 resin was used to capture compound 1 from the aqueous fraction, which was purified by additional chromatographic steps. The absolute configuration of the amino acids of 1 was determined by advanced Marfey's analysis using 5-fluoro-2,4-dinitrophenyl-Nα-L-tryptophanamide. The amino acid derivatives analyzed by ultra-performance liquid chromatography coupled to a mass spectrometry using a C8 column enabled a good chromatographic resolution of L-Ile and L-allo-Ile, previously unfeasible using C18 column. (AU) | |
| FAPESP's process: | 16/16033-3 - Bromopyrrole alkaloids from the Cultured Microbiome of the Marine Sponge Tedania brasiliensis |
| Grantee: | Jairo Iván Quintana Bulla |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 13/50228-8 - Biodiversity components, and their metabolic characters, of Brazilian Islands: an integrated approach |
| Grantee: | Roberto Gomes de Souza Berlinck |
| Support Opportunities: | BIOTA-FAPESP Program - Thematic Grants |