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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Clathriamide, an hexapeptide isolated from the marine sponge Clathria (Clathria) nicoleae

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Author(s):
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Freire, Vitor F. [1] ; Slivinski, Juliano [1] ; Quintana-Bulla, Jairo I. [1] ; Moraes, Fernando C. [2] ; Paradas, Wladimir C. [2] ; Salgado, Leonardo T. [2] ; Pereira, Renato C. [2, 3] ; Moura, Rodrigo L. [4, 5] ; Amado-Filho, Gilberto M. [2] ; Ferreira, Antonio G. [6] ; Berlinck, Roberto G. S. [1]
Total Authors: 11
Affiliation:
[1] Univ Sao Paulo, Inst Quim Sao Carlos, Sao Carlos, SP - Brazil
[2] Inst Pesquisas Jardim Bot Rio de Janeiro, Rio De Janeiro, RJ - Brazil
[3] Univ Fed Fluminense, Dept Biol Marinha, Niteroi, RJ - Brazil
[4] Univ Fed Rio de Janeiro, Inst Biol, Rio De Janeiro, RJ - Brazil
[5] Univ Fed Rio de Janeiro, Lab Sistemas Avancados Gestao, Inst Alberto Luiz Coimbra Posgrad & Pesquisa Engn, Rio De Janeiro, RJ - Brazil
[6] Univ Fed Sao Carlos, Dept Quim, Sao Carlos, SP - Brazil
Total Affiliations: 6
Document type: Journal article
Source: REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY; v. 29, n. 6, p. 715-719, NOV-DEC 2019.
Web of Science Citations: 0
Abstract

ABSTRACT Chemical investigation of the aqueous fraction of the ethanol extract from the Brazilian endemic marine sponge Clathria (Clathria) nicoleae Vieira de Barros, Santos & Pinheiro, 2013, Microcionidae, sampled from a 55 m deep rhodolith bed at the Amazon River mouth, led to the isolation of a new hexapeptide, clathriamide (1). HP-20 resin was used to capture compound 1 from the aqueous fraction, which was purified by additional chromatographic steps. The absolute configuration of the amino acids of 1 was determined by advanced Marfey's analysis using 5-fluoro-2,4-dinitrophenyl-Nα-L-tryptophanamide. The amino acid derivatives analyzed by ultra-performance liquid chromatography coupled to a mass spectrometry using a C8 column enabled a good chromatographic resolution of L-Ile and L-allo-Ile, previously unfeasible using C18 column. (AU)

FAPESP's process: 16/16033-3 - Bromopyrrole alkaloids from the Cultured Microbiome of the Marine Sponge Tedania brasiliensis
Grantee:Jairo Iván Quintana Bulla
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 13/50228-8 - Biodiversity components, and their metabolic characters, of Brazilian Islands: an integrated approach
Grantee:Roberto Gomes de Souza Berlinck
Support Opportunities: BIOTA-FAPESP Program - Thematic Grants